TY - JOUR
T1 - The effect of newly diagnosed undifferentiated connective tissue disease on pregnancy outcome
AU - Spinillo, Arsenio
AU - Beneventi, Fausta
AU - Epis, Oscar M.
AU - Montanari, Laura
AU - Mammoliti, Deborah
AU - Ramoni, Veronique
AU - Di Silverio, Elena
AU - Alpini, Claudia
AU - Caporali, Roberto
AU - Montecucco, Carlomaurizio
PY - 2008/12
Y1 - 2008/12
N2 - Objective: The purpose of this study was to evaluate pregnancy outcome in a cohort of patients with newly diagnosed undifferentiated connective tissue disease (UCTD). Study Design: We conducted a nested case-control study that compared 41 patients who had early UCTD that was diagnosed at 11-14 weeks of pregnancy with 82 healthy control subjects. Results: During pregnancy, UCTD progressed to a definite connective tissue disease in 2 of 41 patients (4.9%). Sixteen of the 41 patients (39%) with UCTD tested positive for anti-Ro (SSA) antibodies. Compared with the control subjects, the women with UCTD had higher rates of small for gestational age (SGA; 12/40 vs 11/80; P = .05). The rate of complications of pregnancy (preterm delivery at ≤ 37 weeks of gestation, SGA, preeclampsia, late fetal loss) was 39% (16/41) among cases and 13.4% (11/82) in control subjects (adjusted odds ratio, 3.98; 95% CI, 1.59-9.49). Conclusion: Pregnant patients with UCTD are at increased risk of SGA and complications of pregnancy.
AB - Objective: The purpose of this study was to evaluate pregnancy outcome in a cohort of patients with newly diagnosed undifferentiated connective tissue disease (UCTD). Study Design: We conducted a nested case-control study that compared 41 patients who had early UCTD that was diagnosed at 11-14 weeks of pregnancy with 82 healthy control subjects. Results: During pregnancy, UCTD progressed to a definite connective tissue disease in 2 of 41 patients (4.9%). Sixteen of the 41 patients (39%) with UCTD tested positive for anti-Ro (SSA) antibodies. Compared with the control subjects, the women with UCTD had higher rates of small for gestational age (SGA; 12/40 vs 11/80; P = .05). The rate of complications of pregnancy (preterm delivery at ≤ 37 weeks of gestation, SGA, preeclampsia, late fetal loss) was 39% (16/41) among cases and 13.4% (11/82) in control subjects (adjusted odds ratio, 3.98; 95% CI, 1.59-9.49). Conclusion: Pregnant patients with UCTD are at increased risk of SGA and complications of pregnancy.
KW - fetal growth restriction
KW - small for gestational age
KW - undifferentiated connective tissue disease
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U2 - 10.1016/j.ajog.2008.05.008
DO - 10.1016/j.ajog.2008.05.008
M3 - Article
C2 - 18667193
AN - SCOPUS:57149123160
VL - 199
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 6
ER -