The effect of newly diagnosed undifferentiated connective tissue disease on pregnancy outcome

Arsenio Spinillo, Fausta Beneventi, Oscar M. Epis, Laura Montanari, Deborah Mammoliti, Veronique Ramoni, Elena Di Silverio, Claudia Alpini, Roberto Caporali, Carlomaurizio Montecucco

Research output: Contribution to journalArticlepeer-review


Objective: The purpose of this study was to evaluate pregnancy outcome in a cohort of patients with newly diagnosed undifferentiated connective tissue disease (UCTD). Study Design: We conducted a nested case-control study that compared 41 patients who had early UCTD that was diagnosed at 11-14 weeks of pregnancy with 82 healthy control subjects. Results: During pregnancy, UCTD progressed to a definite connective tissue disease in 2 of 41 patients (4.9%). Sixteen of the 41 patients (39%) with UCTD tested positive for anti-Ro (SSA) antibodies. Compared with the control subjects, the women with UCTD had higher rates of small for gestational age (SGA; 12/40 vs 11/80; P = .05). The rate of complications of pregnancy (preterm delivery at ≤ 37 weeks of gestation, SGA, preeclampsia, late fetal loss) was 39% (16/41) among cases and 13.4% (11/82) in control subjects (adjusted odds ratio, 3.98; 95% CI, 1.59-9.49). Conclusion: Pregnant patients with UCTD are at increased risk of SGA and complications of pregnancy.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6
Publication statusPublished - Dec 2008


  • fetal growth restriction
  • small for gestational age
  • undifferentiated connective tissue disease

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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