The effect of number of mutations and of drug-class sparing on virological response to salvage genotype-guided antiretroviral therapy

Bruno Christian Ciancio, Maria Paola Trotta, Patrizia Lorenzini, Federica Forbici, Ubaldo Visco-Comandini, Caterina Gori, Sandro Bonfigli, Maria Concetta Bellocchi, Pietro Sette, Roberta D'Arrigo, Valerio Tozzi, Mauro Zaccarelli, Evangelo Boumis, Pasquale Narciso, Carlo Federico Perno, Andrea Antinori

Research output: Contribution to journalArticle

Abstract

Objective: To assess on longitudinal data the impact of number of drug-associated mutations at genotype resistance testing (GRT) and history of previous exposure to antiretrovirals on the virological response to genotype-guided antiretroviral therapy. Methods: Subjects that failed HAART who underwent GRT between June 1999 and March 2002 were enrolled. GRT was performed by Viroseq-2 with expert advice offered to physicians. Main outcome was reaching undetectable (

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalAntiviral Therapy
Volume8
Issue number6
Publication statusPublished - Dec 2003

ASJC Scopus subject areas

  • Pharmacology

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