The effect of number of mutations and of drug-class sparing on virological response to salvage genotype-guided antiretroviral therapy

Bruno Christian Ciancio, Maria Paola Trotta, Patrizia Lorenzini, Federica Forbici, Ubaldo Visco-Comandini, Caterina Gori, Sandro Bonfigli, Maria Concetta Bellocchi, Pietro Sette, Roberta D'Arrigo, Valerio Tozzi, Mauro Zaccarelli, Evangelo Boumis, Pasquale Narciso, Carlo Federico Perno, Andrea Antinori

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To assess on longitudinal data the impact of number of drug-associated mutations at genotype resistance testing (GRT) and history of previous exposure to antiretrovirals on the virological response to genotype-guided antiretroviral therapy. Methods: Subjects that failed HAART who underwent GRT between June 1999 and March 2002 were enrolled. GRT was performed by Viroseq-2 with expert advice offered to physicians. Main outcome was reaching undetectable (

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalAntiviral Therapy
Volume8
Issue number6
Publication statusPublished - Dec 2003

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Genotype
Mutation
Pharmaceutical Preparations
Highly Active Antiretroviral Therapy
Therapeutics
Physicians

ASJC Scopus subject areas

  • Pharmacology

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The effect of number of mutations and of drug-class sparing on virological response to salvage genotype-guided antiretroviral therapy. / Ciancio, Bruno Christian; Trotta, Maria Paola; Lorenzini, Patrizia; Forbici, Federica; Visco-Comandini, Ubaldo; Gori, Caterina; Bonfigli, Sandro; Bellocchi, Maria Concetta; Sette, Pietro; D'Arrigo, Roberta; Tozzi, Valerio; Zaccarelli, Mauro; Boumis, Evangelo; Narciso, Pasquale; Perno, Carlo Federico; Antinori, Andrea.

In: Antiviral Therapy, Vol. 8, No. 6, 12.2003, p. 611-616.

Research output: Contribution to journalArticle

Ciancio, Bruno Christian ; Trotta, Maria Paola ; Lorenzini, Patrizia ; Forbici, Federica ; Visco-Comandini, Ubaldo ; Gori, Caterina ; Bonfigli, Sandro ; Bellocchi, Maria Concetta ; Sette, Pietro ; D'Arrigo, Roberta ; Tozzi, Valerio ; Zaccarelli, Mauro ; Boumis, Evangelo ; Narciso, Pasquale ; Perno, Carlo Federico ; Antinori, Andrea. / The effect of number of mutations and of drug-class sparing on virological response to salvage genotype-guided antiretroviral therapy. In: Antiviral Therapy. 2003 ; Vol. 8, No. 6. pp. 611-616.
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