The effect of opiate treatment on the postdecapitation reflex and monoamine metabolism in the rat spinal cord

Adam Plaznik, Maria Grazia de Simoni, Sergio Algeri

Research output: Contribution to journalArticle

Abstract

Postdecapitation seizures (PDR) are a spinal reflex which seems regulated by some monoaminergic neurons present in the spinal cord (S.C.). In order to better characterize the role of dopaminergic neurons in PDR, we studied the effect of treatment with opiates, which are known to increase dopamine (DA) and serotonin (5HT) metabolism in the brain, on the duration of PDR and on the metabolism of DA and 5HT in S.C. Morphine, given either IP or ICV, reduced the duration of PDR and increased DA metabolism. Both effects were more evident after systematic administration. [D-Ala2]Met5 enkephalin amide acted similarly to ICV administered morphine. Biochemical and behavioral effects were significantly correlated.

Original languageEnglish
Pages (from-to)427-429
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume19
Issue number3
DOIs
Publication statusPublished - 1983

Keywords

  • Dopamine
  • Dopamine metabolism
  • Postdecapitation reflex
  • Spinal cord

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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