The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis

Matthew Warrender-Sparkes; Tim Spelman; Guillermo Izquierdo; Maria Trojano; Alessandra Lugaresi; François Grand'Maison; Eva Havrdova; Dana Horakova; Cavit Boz; Celia Oreja-Guevara; Raed Alroughani; Gerardo Iuliano; Pierre Duquette; Marc Girard; Murat Terzi; Raymond Hupperts; Pierre Grammond; Thor Petersen; Ricardo Fernandez-Bolaños; Marcela Fiol; Eugenio Pucci; Jeannette Lechner-Scott; Freek Verheul; Edgardo Cristiano; Vincent Van Pesch; Tatjana Petkovska-Boskova; Fraser Moore; Ilya Kister; Roberto Bergamaschi; Maria Laura Saladino; Mark Slee; Michael Barnett; Maria Pia Amato; Cameron Shaw; Neil Shuey; Carolyn Young; Orla Gray; Ludwig Kappos; Helmut Butzkueven; Tomas Kalincik; Vilija Jokubaitis

doi:10.1177/1352458515594041

The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis

Matthew Warrender-Sparkes, Tim Spelman, Guillermo Izquierdo, Maria Trojano, Alessandra Lugaresi, François Grand'Maison, Eva Havrdova, Dana Horakova, Cavit Boz, Celia Oreja-Guevara, Raed Alroughani, Gerardo Iuliano, Pierre Duquette, Marc Girard, Murat Terzi, Raymond Hupperts, Pierre Grammond, Thor Petersen, Ricardo Fernandez-Bolaños, Marcela FiolEugenio Pucci, Jeannette Lechner-Scott, Freek Verheul, Edgardo Cristiano, Vincent Van Pesch, Tatjana Petkovska-Boskova, Fraser Moore, Ilya Kister, Roberto Bergamaschi, Maria Laura Saladino, Mark Slee, Michael Barnett, Maria Pia Amato, Cameron Shaw, Neil Shuey, Carolyn Young, Orla Gray, Ludwig Kappos, Helmut Butzkueven, Tomas Kalincik, Vilija Jokubaitis

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: We aimed to analyse the effect of the introduction of fingolimod, the first oral disease-modifying therapy, on treatment utilisation and persistence in an international cohort of patients with multiple sclerosis (MS). Methods: MSBASIS, a prospective, observational sub-study of the MSBase registry, collects demographic, clinical and paraclinical data on patients followed from MS onset (n=4718). We conducted a multivariable conditional risk set survival analysis to identify predictors of treatment discontinuation, and to assess if the introduction of fingolimod has altered treatment persistence. Results: A total of 2640 patients commenced immunomodulatory therapy. Following the introduction of fingolimod, patients were more likely to discontinue all other treatments (hazard ratio 1.64, p

Original language	English
Pages (from-to)	520-532
Number of pages	13
Journal	Multiple Sclerosis Journal
Volume	22
Issue number	4
DOIs	https://doi.org/10.1177/1352458515594041
Publication status	Published - Apr 1 2016

Keywords

disease-modifying therapy
fingolimod
medication persistence
MSBase
Multiple sclerosis

ASJC Scopus subject areas

Clinical Neurology
Neurology

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Warrender-Sparkes, M., Spelman, T., Izquierdo, G., Trojano, M., Lugaresi, A., Grand'Maison, F., Havrdova, E., Horakova, D., Boz, C., Oreja-Guevara, C., Alroughani, R., Iuliano, G., Duquette, P., Girard, M., Terzi, M., Hupperts, R., Grammond, P., Petersen, T., Fernandez-Bolaños, R., ... Jokubaitis, V. (2016). The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis. Multiple Sclerosis Journal, 22(4), 520-532. https://doi.org/10.1177/1352458515594041

The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis. / Warrender-Sparkes, Matthew; Spelman, Tim; Izquierdo, Guillermo; Trojano, Maria; Lugaresi, Alessandra; Grand'Maison, François; Havrdova, Eva; Horakova, Dana; Boz, Cavit; Oreja-Guevara, Celia; Alroughani, Raed; Iuliano, Gerardo; Duquette, Pierre; Girard, Marc; Terzi, Murat; Hupperts, Raymond; Grammond, Pierre; Petersen, Thor; Fernandez-Bolaños, Ricardo; Fiol, Marcela; Pucci, Eugenio; Lechner-Scott, Jeannette; Verheul, Freek; Cristiano, Edgardo; Van Pesch, Vincent; Petkovska-Boskova, Tatjana; Moore, Fraser; Kister, Ilya; Bergamaschi, Roberto; Saladino, Maria Laura; Slee, Mark; Barnett, Michael; Amato, Maria Pia; Shaw, Cameron; Shuey, Neil; Young, Carolyn; Gray, Orla; Kappos, Ludwig; Butzkueven, Helmut; Kalincik, Tomas; Jokubaitis, Vilija.

In: Multiple Sclerosis Journal, Vol. 22, No. 4, 01.04.2016, p. 520-532.

Research output: Contribution to journal › Article › peer-review

Warrender-Sparkes, M, Spelman, T, Izquierdo, G, Trojano, M, Lugaresi, A, Grand'Maison, F, Havrdova, E, Horakova, D, Boz, C, Oreja-Guevara, C, Alroughani, R, Iuliano, G, Duquette, P, Girard, M, Terzi, M, Hupperts, R, Grammond, P, Petersen, T, Fernandez-Bolaños, R, Fiol, M, Pucci, E, Lechner-Scott, J, Verheul, F, Cristiano, E, Van Pesch, V, Petkovska-Boskova, T, Moore, F, Kister, I, Bergamaschi, R, Saladino, ML, Slee, M, Barnett, M, Amato, MP, Shaw, C, Shuey, N, Young, C, Gray, O, Kappos, L, Butzkueven, H, Kalincik, T & Jokubaitis, V 2016, 'The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis', Multiple Sclerosis Journal, vol. 22, no. 4, pp. 520-532. https://doi.org/10.1177/1352458515594041

Warrender-Sparkes, Matthew ; Spelman, Tim ; Izquierdo, Guillermo ; Trojano, Maria ; Lugaresi, Alessandra ; Grand'Maison, François ; Havrdova, Eva ; Horakova, Dana ; Boz, Cavit ; Oreja-Guevara, Celia ; Alroughani, Raed ; Iuliano, Gerardo ; Duquette, Pierre ; Girard, Marc ; Terzi, Murat ; Hupperts, Raymond ; Grammond, Pierre ; Petersen, Thor ; Fernandez-Bolaños, Ricardo ; Fiol, Marcela ; Pucci, Eugenio ; Lechner-Scott, Jeannette ; Verheul, Freek ; Cristiano, Edgardo ; Van Pesch, Vincent ; Petkovska-Boskova, Tatjana ; Moore, Fraser ; Kister, Ilya ; Bergamaschi, Roberto ; Saladino, Maria Laura ; Slee, Mark ; Barnett, Michael ; Amato, Maria Pia ; Shaw, Cameron ; Shuey, Neil ; Young, Carolyn ; Gray, Orla ; Kappos, Ludwig ; Butzkueven, Helmut ; Kalincik, Tomas ; Jokubaitis, Vilija. / The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis. In: Multiple Sclerosis Journal. 2016 ; Vol. 22, No. 4. pp. 520-532.

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