The effect of osteopenia on the osteointegration of different biomaterials: Histomorphometric study in rats

M. Fini, G. Giavaresi, N. Nicoli Aldini, P. Torricelli, G. Morrone, G. A. Guzzardella, R. Giardino, A. Krajewski, A. Ravaglioli, M. Mattioli Belmonte, A. De Benedittis, G. Biagini

Research output: Contribution to journalArticlepeer-review


The osteointegration of Hydroxyapatite (HA), Titanium (Ti-6Al-4V: Ti), Zirconia (ZrO2), Alumina (Al2O3) and 2 biological glasses (AP40 and RKKP) was comparatively investigated in normal and osteopenic rats by means of histomorphometry. Thirty-six Sprague Dawley female rats were left intact (Group C) while 36 were ovariectomized (Group OVX). Group C and OVX were further divided into 6 subgroups. After 16 weeks all animals were submitted to the femoral implant of nails made of the above-mentioned materials. Eight weeks after implantation the animals were euthanized, the femurs were harvested for histomorphometric analysis. The data showed that: (1) all the tested materials were biocompatible in vitro; (2) no significant differences existed in Affinity Index (Al) of Group C; and (3) results from paired comparison applied to the Al showed significant differences among the Groups C and OVX. The Al did not significantly change among intact groups, while it significantly decreased when some materials were implanted in OVX subgroups (AP40, ZrO2 and Ti-6Al-4V: p <0.0005, p <0.05 and p <0.01). It is confirmed that bone mineral density is a strong predictor of the osteointegration of an orthopedic implant and that the use of pathological animal models is necessary to completely characterize biomaterials. (C) 2000 Kluwer Academic Publishers.

Original languageEnglish
Pages (from-to)579-585
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Issue number9
Publication statusPublished - Sep 2000

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Chemical Engineering(all)


Dive into the research topics of 'The effect of osteopenia on the osteointegration of different biomaterials: Histomorphometric study in rats'. Together they form a unique fingerprint.

Cite this