The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat

L. Manzo, R. Passoni, A. D. Segre, F. Bertè, A. Crema

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Oxine-5-sulphonic acid inhibits the metabolism of aminopyrine in the rat liver in vitro. The characteristics of this inhibition vary according to whether the oxidative N-demethylation of the substrate is determined by the formation of the metabolite 4-aminoantipyrine or by the production of formaldehyde.

Original languageEnglish
Pages (from-to)1318-1320
Number of pages3
JournalExperientia
Volume32
Issue number10
DOIs
Publication statusPublished - Oct 1976

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Ampyrone
Aminopyrine
Metabolites
Metabolism
Liver
Formaldehyde
Rats
Substrates
Pharmaceutical Preparations
8-hydroxyquinoline-5-sulfonic acid
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Manzo, L., Passoni, R., Segre, A. D., Bertè, F., & Crema, A. (1976). The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat. Experientia, 32(10), 1318-1320. https://doi.org/10.1007/BF01953115

The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat. / Manzo, L.; Passoni, R.; Segre, A. D.; Bertè, F.; Crema, A.

In: Experientia, Vol. 32, No. 10, 10.1976, p. 1318-1320.

Research output: Contribution to journalArticle

Manzo, L, Passoni, R, Segre, AD, Bertè, F & Crema, A 1976, 'The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat', Experientia, vol. 32, no. 10, pp. 1318-1320. https://doi.org/10.1007/BF01953115
Manzo, L. ; Passoni, R. ; Segre, A. D. ; Bertè, F. ; Crema, A. / The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat. In: Experientia. 1976 ; Vol. 32, No. 10. pp. 1318-1320.
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