The aim of our study is to demonstrate age-related heamodynamic, electrical and mechanical modifications induced by phosphoglycerides. These substance are usually evident both in physiological and pathological conditions. Lysophosphatidylcholine, at concentration similar to that observed in ischemic myocardium, induces severe age-related ventricular arrhythmias that were exacerbated by epinephrine. Since lysophosphatidylcholine arrhythmogenic effect was related to left ventricular dysfunction, the greater severity of ventricular arrhythmias induced by lysophosphatidylcholine should be explained by mechanical modifications present at rest in aging heart that might counteract with lysophosphatidylcholine arrhythmogenic effect. Phosphorylcholine (Platelet activating factor, PAF), on the contrary, provokes a marked age-related reduction on myocardial contractility and coronary flow rate with atrioventricular conduction disturbance. Since lyso-PAF did not modify while specific compounds CV-3988 inhibited all electro-mechanical response both in adult and senescent hearts, PAF acts on receptors, whose function is unaffected by age.
|Translated title of the contribution||The effect of phosphoglycerides on electrical, mechanical and hemodynamic modifications induces aging of the cardiac muscle|
|Number of pages||10|
|Publication status||Published - 1995|
ASJC Scopus subject areas
- Geriatrics and Gerontology