L'EFFETTO DEI FOSFOGLICERIDI SULLE MODIFICAZIONI ELETTRICHE, MECCANICHE ED EMODINAMICHE INDOTTE DALL'INVECCHIAMENTO NEL MUSCOLO CARDIACO

Translated title of the contribution: The effect of phosphoglycerides on electrical, mechanical and hemodynamic modifications induces aging of the cardiac muscle

S. Bianco, C. Calabrese, P. Ferrara, P. Landino, P. Abete, N. Ferrara, F. Rengo

Research output: Contribution to journalArticle

Abstract

The aim of our study is to demonstrate age-related heamodynamic, electrical and mechanical modifications induced by phosphoglycerides. These substance are usually evident both in physiological and pathological conditions. Lysophosphatidylcholine, at concentration similar to that observed in ischemic myocardium, induces severe age-related ventricular arrhythmias that were exacerbated by epinephrine. Since lysophosphatidylcholine arrhythmogenic effect was related to left ventricular dysfunction, the greater severity of ventricular arrhythmias induced by lysophosphatidylcholine should be explained by mechanical modifications present at rest in aging heart that might counteract with lysophosphatidylcholine arrhythmogenic effect. Phosphorylcholine (Platelet activating factor, PAF), on the contrary, provokes a marked age-related reduction on myocardial contractility and coronary flow rate with atrioventricular conduction disturbance. Since lyso-PAF did not modify while specific compounds CV-3988 inhibited all electro-mechanical response both in adult and senescent hearts, PAF acts on receptors, whose function is unaffected by age.

Original languageItalian
Pages (from-to)237-246
Number of pages10
JournalGeriatria
Volume7
Issue number4
Publication statusPublished - 1995

Fingerprint

Glycerophospholipids
Lysophosphatidylcholines
Myocardium
Hemodynamics
Platelet Activating Factor
Cardiac Arrhythmias
Phosphorylcholine
Left Ventricular Dysfunction
Epinephrine

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Bianco, S., Calabrese, C., Ferrara, P., Landino, P., Abete, P., Ferrara, N., & Rengo, F. (1995). L'EFFETTO DEI FOSFOGLICERIDI SULLE MODIFICAZIONI ELETTRICHE, MECCANICHE ED EMODINAMICHE INDOTTE DALL'INVECCHIAMENTO NEL MUSCOLO CARDIACO. Geriatria, 7(4), 237-246.

L'EFFETTO DEI FOSFOGLICERIDI SULLE MODIFICAZIONI ELETTRICHE, MECCANICHE ED EMODINAMICHE INDOTTE DALL'INVECCHIAMENTO NEL MUSCOLO CARDIACO. / Bianco, S.; Calabrese, C.; Ferrara, P.; Landino, P.; Abete, P.; Ferrara, N.; Rengo, F.

In: Geriatria, Vol. 7, No. 4, 1995, p. 237-246.

Research output: Contribution to journalArticle

Bianco, S, Calabrese, C, Ferrara, P, Landino, P, Abete, P, Ferrara, N & Rengo, F 1995, 'L'EFFETTO DEI FOSFOGLICERIDI SULLE MODIFICAZIONI ELETTRICHE, MECCANICHE ED EMODINAMICHE INDOTTE DALL'INVECCHIAMENTO NEL MUSCOLO CARDIACO', Geriatria, vol. 7, no. 4, pp. 237-246.
Bianco, S. ; Calabrese, C. ; Ferrara, P. ; Landino, P. ; Abete, P. ; Ferrara, N. ; Rengo, F. / L'EFFETTO DEI FOSFOGLICERIDI SULLE MODIFICAZIONI ELETTRICHE, MECCANICHE ED EMODINAMICHE INDOTTE DALL'INVECCHIAMENTO NEL MUSCOLO CARDIACO. In: Geriatria. 1995 ; Vol. 7, No. 4. pp. 237-246.
@article{1a72457a8d2844a49880f309a69b3947,
title = "L'EFFETTO DEI FOSFOGLICERIDI SULLE MODIFICAZIONI ELETTRICHE, MECCANICHE ED EMODINAMICHE INDOTTE DALL'INVECCHIAMENTO NEL MUSCOLO CARDIACO",
abstract = "The aim of our study is to demonstrate age-related heamodynamic, electrical and mechanical modifications induced by phosphoglycerides. These substance are usually evident both in physiological and pathological conditions. Lysophosphatidylcholine, at concentration similar to that observed in ischemic myocardium, induces severe age-related ventricular arrhythmias that were exacerbated by epinephrine. Since lysophosphatidylcholine arrhythmogenic effect was related to left ventricular dysfunction, the greater severity of ventricular arrhythmias induced by lysophosphatidylcholine should be explained by mechanical modifications present at rest in aging heart that might counteract with lysophosphatidylcholine arrhythmogenic effect. Phosphorylcholine (Platelet activating factor, PAF), on the contrary, provokes a marked age-related reduction on myocardial contractility and coronary flow rate with atrioventricular conduction disturbance. Since lyso-PAF did not modify while specific compounds CV-3988 inhibited all electro-mechanical response both in adult and senescent hearts, PAF acts on receptors, whose function is unaffected by age.",
keywords = "aging heart, lysophosphatidylcholine, platelet activating factor",
author = "S. Bianco and C. Calabrese and P. Ferrara and P. Landino and P. Abete and N. Ferrara and F. Rengo",
year = "1995",
language = "Italian",
volume = "7",
pages = "237--246",
journal = "Geriatria",
issn = "1122-5807",
publisher = "Casa Editrice Scientifica Internazionale Periodici",
number = "4",

}

TY - JOUR

T1 - L'EFFETTO DEI FOSFOGLICERIDI SULLE MODIFICAZIONI ELETTRICHE, MECCANICHE ED EMODINAMICHE INDOTTE DALL'INVECCHIAMENTO NEL MUSCOLO CARDIACO

AU - Bianco, S.

AU - Calabrese, C.

AU - Ferrara, P.

AU - Landino, P.

AU - Abete, P.

AU - Ferrara, N.

AU - Rengo, F.

PY - 1995

Y1 - 1995

N2 - The aim of our study is to demonstrate age-related heamodynamic, electrical and mechanical modifications induced by phosphoglycerides. These substance are usually evident both in physiological and pathological conditions. Lysophosphatidylcholine, at concentration similar to that observed in ischemic myocardium, induces severe age-related ventricular arrhythmias that were exacerbated by epinephrine. Since lysophosphatidylcholine arrhythmogenic effect was related to left ventricular dysfunction, the greater severity of ventricular arrhythmias induced by lysophosphatidylcholine should be explained by mechanical modifications present at rest in aging heart that might counteract with lysophosphatidylcholine arrhythmogenic effect. Phosphorylcholine (Platelet activating factor, PAF), on the contrary, provokes a marked age-related reduction on myocardial contractility and coronary flow rate with atrioventricular conduction disturbance. Since lyso-PAF did not modify while specific compounds CV-3988 inhibited all electro-mechanical response both in adult and senescent hearts, PAF acts on receptors, whose function is unaffected by age.

AB - The aim of our study is to demonstrate age-related heamodynamic, electrical and mechanical modifications induced by phosphoglycerides. These substance are usually evident both in physiological and pathological conditions. Lysophosphatidylcholine, at concentration similar to that observed in ischemic myocardium, induces severe age-related ventricular arrhythmias that were exacerbated by epinephrine. Since lysophosphatidylcholine arrhythmogenic effect was related to left ventricular dysfunction, the greater severity of ventricular arrhythmias induced by lysophosphatidylcholine should be explained by mechanical modifications present at rest in aging heart that might counteract with lysophosphatidylcholine arrhythmogenic effect. Phosphorylcholine (Platelet activating factor, PAF), on the contrary, provokes a marked age-related reduction on myocardial contractility and coronary flow rate with atrioventricular conduction disturbance. Since lyso-PAF did not modify while specific compounds CV-3988 inhibited all electro-mechanical response both in adult and senescent hearts, PAF acts on receptors, whose function is unaffected by age.

KW - aging heart

KW - lysophosphatidylcholine

KW - platelet activating factor

UR - http://www.scopus.com/inward/record.url?scp=0029562058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029562058&partnerID=8YFLogxK

M3 - Articolo

AN - SCOPUS:0029562058

VL - 7

SP - 237

EP - 246

JO - Geriatria

JF - Geriatria

SN - 1122-5807

IS - 4

ER -