The effect of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboons

Antonio Francavilla, Arthur F. Jones, Joseph Benichou, Thomas E. Starzl

Research output: Contribution to journalArticle

Abstract

Hepatic cholesterol synthesis, hepatic cyclic AMP, and portal and peripheral insulin and glucagon levels were investigated in nine dogs and three baboons after complete portacaval shunt. Cholesterol synthesis as measured with acetate incorporation was reduced in both species. Hepatic cyclic AMP increased in dogs. Changes in portal and systemic insulin were inconsistent, but hyperglucagonemia occurred regularly. Diminished hepatic cholesterol synthesis is apparently one factor, although probably not the only one, in the antilipidemic effect of portacaval shunt. This altered cholesterol metabolism may be due to a change in the hormonal environment of the liver caused by portal diversion.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of Surgical Research
Volume28
Issue number1
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Surgery

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