The effect of pulsed electromagnetic fields on the osteointegration of hydroxyapatite implants in cancellous bone: A morphologic and microstructural in vivo study

Milena Fini, Ruggero Cadossi, Valerio Canè, Francesco Cavani, Gianluca Giavaresi, Adriano Krajewski, Lucia Martini, Nicolò Nicoli Aldini, Antonio Ravaglioli, Lia Rimondini, Paola Torricelli, Roberto Giardino

Research output: Contribution to journalArticle

Abstract

Effects of pulsed electromagnetic fields (PEMFs, 75 Hz, 1.6 mT) were investigated in 12 rabbits after placing hydroxyapatite (HA) implants in their femoral condyles. Six animals were stimulated with PEMFs for three consecutive weeks, 6 h/day, while the remaining animals were sham-treated (Control Group). Rabbits were sacrificed at 3 and 6 weeks (after a 3-week non-stimulation period) for histomorphometric analysis and microhardness testing (at 200, 500, 1000, 2000 μm from the implant) around the implants. Histomorphometric analysis did not highlight any significant changes. On the contrary, there were statistically significant differences between the effects produced by PEMFs and Control Groups (F = 149.70, p <0.0005) on the Affinity Index results, as well as by the experimental time of 6 and 3 weeks (F = 17.12, p = 0.001) on the same results. In PEMF-stimulated animals the microhardness (HV) values measured in trabecular bone at a distance of 200 and 500 μm from the implants, were significantly higher with respect to controls. At 6 weeks, HV values at the bone-implant interface in PEMF-stimulated animals were not significantly different with respect to normal bone, while they remained significantly lower in control animals. Both morphological and structural results demonstrated a positive therapeutic effect of PEMFs in accelerating HA osteointegration in trabecular bone.

Original languageEnglish
Pages (from-to)756-763
Number of pages8
JournalJournal of Orthopaedic Research
Volume20
Issue number4
DOIs
Publication statusPublished - 2002

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Electromagnetic Fields
Durapatite
Rabbits
Bone and Bones
Control Groups
Therapeutic Uses
Thigh
Demography
Cancellous Bone

Keywords

  • Electromagnetic field
  • Hydroxyapatite
  • Osteointegration
  • Rabbits

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

The effect of pulsed electromagnetic fields on the osteointegration of hydroxyapatite implants in cancellous bone : A morphologic and microstructural in vivo study. / Fini, Milena; Cadossi, Ruggero; Canè, Valerio; Cavani, Francesco; Giavaresi, Gianluca; Krajewski, Adriano; Martini, Lucia; Nicoli Aldini, Nicolò; Ravaglioli, Antonio; Rimondini, Lia; Torricelli, Paola; Giardino, Roberto.

In: Journal of Orthopaedic Research, Vol. 20, No. 4, 2002, p. 756-763.

Research output: Contribution to journalArticle

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