The effect of re-operation on survival in patients with recurrent glioblastoma

Enrico Franceschi, Marco Bartolotti, Alicia Tosoni, Stefania Bartolini, Carmelo Sturiale, Antonio Fioravanti, Eugenio Pozzati, Renato Galzio, Andrea Talacchi, Lorenzo Volpin, Luca Morandi, Daniela Danieli, Mario Ermani, Alba A. Brandes

Research output: Contribution to journalArticle

Abstract

Background: Treatment options for glioblastoma (GBM) at recurrence have limited efficacy. Re-surgery has been used for confirmation of recurrent disease and to provide relief of symptoms but the real impact on survival is unknown. Patients and Methods: A retrospective analysis was performed for GBM patients followed between 01/2005 and 06/2010 at our Institution. Results: Two hundred and thirtytwo patients with recurrent GBM were evaluated. One hundred and two patients (44%) were treated with re-surgery followed by chemotherapy and 130 patients (56%) with chemotherapy alone. In multivariate analysis, no significant effect of re-surgery was found, with age (p=0.001), MGMT methylation (p=0.002) and PFS at 6 months (p=0.0001) being significant prognostic factors. Conclusion: Second surgery might have a limited impact in the clinical course of recurrent GBM patients.

Original languageEnglish
Pages (from-to)1743-1748
Number of pages6
JournalAnticancer Research
Volume35
Issue number3
Publication statusPublished - Mar 1 2015

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Keywords

  • Glioblastoma
  • Radiotherapy
  • Second surgery
  • Surgery
  • Temozolomide

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Franceschi, E., Bartolotti, M., Tosoni, A., Bartolini, S., Sturiale, C., Fioravanti, A., Pozzati, E., Galzio, R., Talacchi, A., Volpin, L., Morandi, L., Danieli, D., Ermani, M., & Brandes, A. A. (2015). The effect of re-operation on survival in patients with recurrent glioblastoma. Anticancer Research, 35(3), 1743-1748.