The effect of re-operation on survival in patients with recurrent glioblastoma

Enrico Franceschi; Marco Bartolotti; Alicia Tosoni; Stefania Bartolini; Carmelo Sturiale; Antonio Fioravanti; Eugenio Pozzati; Renato Galzio; Andrea Talacchi; Lorenzo Volpin; Luca Morandi; Daniela Danieli; Mario Ermani; Alba A. Brandes

The effect of re-operation on survival in patients with recurrent glioblastoma

Enrico Franceschi, Marco Bartolotti, Alicia Tosoni, Stefania Bartolini, Carmelo Sturiale, Antonio Fioravanti, Eugenio Pozzati, Renato Galzio, Andrea Talacchi, Lorenzo Volpin, Luca Morandi, Daniela Danieli, Mario Ermani, Alba A. Brandes

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Treatment options for glioblastoma (GBM) at recurrence have limited efficacy. Re-surgery has been used for confirmation of recurrent disease and to provide relief of symptoms but the real impact on survival is unknown. Patients and Methods: A retrospective analysis was performed for GBM patients followed between 01/2005 and 06/2010 at our Institution. Results: Two hundred and thirtytwo patients with recurrent GBM were evaluated. One hundred and two patients (44%) were treated with re-surgery followed by chemotherapy and 130 patients (56%) with chemotherapy alone. In multivariate analysis, no significant effect of re-surgery was found, with age (p=0.001), MGMT methylation (p=0.002) and PFS at 6 months (p=0.0001) being significant prognostic factors. Conclusion: Second surgery might have a limited impact in the clinical course of recurrent GBM patients.

Original language	English
Pages (from-to)	1743-1748
Number of pages	6
Journal	Anticancer Research
Volume	35
Issue number	3
Publication status	Published - Mar 1 2015

Keywords

Glioblastoma
Radiotherapy
Second surgery
Surgery
Temozolomide

ASJC Scopus subject areas

Cancer Research
Oncology
Medicine(all)

Cite this

The effect of re-operation on survival in patients with recurrent glioblastoma. / Franceschi, Enrico; Bartolotti, Marco; Tosoni, Alicia; Bartolini, Stefania; Sturiale, Carmelo; Fioravanti, Antonio; Pozzati, Eugenio; Galzio, Renato; Talacchi, Andrea; Volpin, Lorenzo; Morandi, Luca; Danieli, Daniela; Ermani, Mario; Brandes, Alba A.

In: Anticancer Research, Vol. 35, No. 3, 01.03.2015, p. 1743-1748.

Research output: Contribution to journal › Article › peer-review

Franceschi, Enrico ; Bartolotti, Marco ; Tosoni, Alicia ; Bartolini, Stefania ; Sturiale, Carmelo ; Fioravanti, Antonio ; Pozzati, Eugenio ; Galzio, Renato ; Talacchi, Andrea ; Volpin, Lorenzo ; Morandi, Luca ; Danieli, Daniela ; Ermani, Mario ; Brandes, Alba A. / The effect of re-operation on survival in patients with recurrent glioblastoma. In: Anticancer Research. 2015 ; Vol. 35, No. 3. pp. 1743-1748.

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AU - Tosoni, Alicia

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AU - Sturiale, Carmelo

AU - Fioravanti, Antonio

AU - Pozzati, Eugenio

AU - Galzio, Renato

AU - Talacchi, Andrea

AU - Volpin, Lorenzo

AU - Morandi, Luca

AU - Danieli, Daniela

AU - Ermani, Mario

AU - Brandes, Alba A.

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N2 - Background: Treatment options for glioblastoma (GBM) at recurrence have limited efficacy. Re-surgery has been used for confirmation of recurrent disease and to provide relief of symptoms but the real impact on survival is unknown. Patients and Methods: A retrospective analysis was performed for GBM patients followed between 01/2005 and 06/2010 at our Institution. Results: Two hundred and thirtytwo patients with recurrent GBM were evaluated. One hundred and two patients (44%) were treated with re-surgery followed by chemotherapy and 130 patients (56%) with chemotherapy alone. In multivariate analysis, no significant effect of re-surgery was found, with age (p=0.001), MGMT methylation (p=0.002) and PFS at 6 months (p=0.0001) being significant prognostic factors. Conclusion: Second surgery might have a limited impact in the clinical course of recurrent GBM patients.

AB - Background: Treatment options for glioblastoma (GBM) at recurrence have limited efficacy. Re-surgery has been used for confirmation of recurrent disease and to provide relief of symptoms but the real impact on survival is unknown. Patients and Methods: A retrospective analysis was performed for GBM patients followed between 01/2005 and 06/2010 at our Institution. Results: Two hundred and thirtytwo patients with recurrent GBM were evaluated. One hundred and two patients (44%) were treated with re-surgery followed by chemotherapy and 130 patients (56%) with chemotherapy alone. In multivariate analysis, no significant effect of re-surgery was found, with age (p=0.001), MGMT methylation (p=0.002) and PFS at 6 months (p=0.0001) being significant prognostic factors. Conclusion: Second surgery might have a limited impact in the clinical course of recurrent GBM patients.

KW - Glioblastoma

KW - Radiotherapy

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The effect of re-operation on survival in patients with recurrent glioblastoma

Abstract

Keywords

ASJC Scopus subject areas

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