Abstract
Background: Treatment options for glioblastoma (GBM) at recurrence have limited efficacy. Re-surgery has been used for confirmation of recurrent disease and to provide relief of symptoms but the real impact on survival is unknown. Patients and Methods: A retrospective analysis was performed for GBM patients followed between 01/2005 and 06/2010 at our Institution. Results: Two hundred and thirtytwo patients with recurrent GBM were evaluated. One hundred and two patients (44%) were treated with re-surgery followed by chemotherapy and 130 patients (56%) with chemotherapy alone. In multivariate analysis, no significant effect of re-surgery was found, with age (p=0.001), MGMT methylation (p=0.002) and PFS at 6 months (p=0.0001) being significant prognostic factors. Conclusion: Second surgery might have a limited impact in the clinical course of recurrent GBM patients.
Original language | English |
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Pages (from-to) | 1743-1748 |
Number of pages | 6 |
Journal | Anticancer Research |
Volume | 35 |
Issue number | 3 |
Publication status | Published - Mar 1 2015 |
Keywords
- Glioblastoma
- Radiotherapy
- Second surgery
- Surgery
- Temozolomide
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)