The effect of recombinant PTH(1-34) and PTH(1-84) on serum ionized calcium, 1,25-dihydroxyvitamin D, and urinary calcium excretion: A pilot study

Sara Piemonte, Elisabetta Romagnoli, Cristiana Cipriani, Valeria Fassino, Romano Del Fiacco, Vincenzo Carnevale, Alfredo Scillitani, Emilio D'Erasmo, Andrea Tancredi, Salvatore Minisola

Research output: Contribution to journalArticle

Abstract

We investigated the frequency of hypercalcemia and/or hypercalciuria following parathyroid hormone (PTH) 1-34 and 1-84 administration in a crossover trial. Ten postmenopausal osteoporotic women previously treated with bisphosphonates were subdivided into two groups of five patients each. A 24-h urine collection to determine baseline calcium (Ca) and creatinine (Cr) the day before administration of PTH was followed by determination of serum ionized Ca (Ca2+), Cr, 25(OH)D, and 1,25(OH)2D at baseline. Thereafter, 100 mcg of PTH(1-84) or 20 mcg of PTH(1-34) was administered. A 24-h urinary collection and blood samples 2, 4, and 24-h after each PTH administration were again taken. One week after the first PTH administration patients were rechallenged with the second PTH. The PTH peptides did not differ with respect to changes in Ca2+ at 2, 4, and 24 h postinjection; at the last time point the values were virtually identical to the initial values. There was no difference in urinary Ca on the day following PTH injection compared to baseline, in terms both of Ca/Cr and of Ca excretion. The two PTH peptides did not differ with respect to changes in 1,25(OH)2D at 2, 4, and 24 h considering both the absolute values and the percent changes with respect to baseline (24-h 1-84 = 125.6 ± 58.6 pg/ml, 153% increase; 1-34 = 124.1 ± 64.7, 130%). Our results indicate no difference in postinjection serum Ca2+, 1,25(OH)2D, or urinary Ca excretion after a single dose of either PTH(1-84) or PTH(1-34) in patients previously treated with bisphosphonates.

Original languageEnglish
Pages (from-to)287-292
Number of pages6
JournalCalcified Tissue International
Volume85
Issue number4
DOIs
Publication statusPublished - Oct 2009

Keywords

  • 1,25(OH) D
  • PTH(1-34)
  • PTH(1-84)
  • Serum ionized calcium
  • Urinary calcium

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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