The effect of repeated whole-body cryostimulation on the HSP-70 and lipid metabolisms in healthy subjects

A. Lubkowska, I. Bryczkowska, Z. Szygula, C. Giemza, A. Skrzek, I. Rotter, G. Lombardi, G. Banfi

Research output: Contribution to journalArticlepeer-review


The aim of this study was to evaluate the effects of exposure to 30 daily whole body cryostimulation (WBC) on lipid metabolic parameters and serum HSP-70 concentration. The study involved 45 volunteers, homogeneous in terms of diet and daily physical activity. Blood samples were collected before and after the 10th, the 20th, and the 30th session and one month after the intervention. Total cholesterol, HDL, TG concentrations and Apolipoprotein A-I, ApoB and HSP-70 protein levels were determined in serum. Additionally, the LI (Lipid Index) and the LDL level were calculated. During exposure, positive changes in the lipid profile that included a decrease in the TCh, initiated after the 20th WBC session with a simultaneous decrease in TG and LDL levels, and an increase in the HDL concentration were observed. These changes were accompanied by a downward trend in the ApoB concentration and a decrease in the ApoB:ApoA-I ratio after 30 sessions. The nature of these changes persisted for a month after the exposure. The obtained results indicate metabolic benefits that result from prolonged exposure to cryogenic temperatures, confirming the postulate of using WBC in the regulation of lipid metabolism and the prevention of cardiovascular diseases.

Original languageEnglish
Pages (from-to)419-429
Number of pages11
JournalPhysiological Research
Issue number3
Publication statusPublished - 2019


  • Cryostimulation
  • Dyslipidemia
  • Heat shock protein
  • Lipid metabolisms

ASJC Scopus subject areas

  • Physiology

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