The effect of repetitive transcranial magnetic stimulation on motor performance, fatigue and quality of life in amyotrophic lateral sclerosis

Giampietro Zanette, Antonio Forgione, Paolo Manganotti, Antonio Fiaschi, Stefano Tamburin

Research output: Contribution to journalArticle

Abstract

Background: The treatment of amyotrophic lateral sclerosis (ALS) is still disappointing. Repetitive transcranial magnetic stimulation (rTMS) has been suggested to modify the rate of disease progression in ALS. Objective: In a pilot controlled study, we tested the effect of 5-Hz rTMS on motor performance, fatigue and quality of life (QoL) in ALS. Methods: Ten ALS patients underwent a two-week period of daily active or sham 5-Hz rTMS. Outcome measures were assessed with functional, fatigue and QoL scales. Muscle strength was evaluated with the MRC scale and measured with isometric and isokinetic dynamometer. Results: Significant difference at the end of rTMS treatment was found for QoL, maximum voluntary isometric contraction and isokinetic average power when comparing active vs sham treatment. These changes were transitory and outcome measures were not significant two weeks after discontinuation of rTMS. Conclusions: Though preliminary, our results suggest that 5-Hz rTMS may improve motor function and QoL in ALS. The present data indicate the need of a double-blind therapeutic trial of rTMS in ALS.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalJournal of the Neurological Sciences
Volume270
Issue number1-2
DOIs
Publication statusPublished - Jul 15 2008

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Transcranial Magnetic Stimulation
Amyotrophic Lateral Sclerosis
Fatigue
Quality of Life
Outcome Assessment (Health Care)
Isometric Contraction
Muscle Strength
Disease Progression
Therapeutics
Placebos

Keywords

  • Amyotrophic lateral sclerosis (ALS)
  • Fatigue
  • Muscle strength
  • Quality of life (QoL)
  • Therapy
  • Transcranial magnetic stimulation (TMS)

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

The effect of repetitive transcranial magnetic stimulation on motor performance, fatigue and quality of life in amyotrophic lateral sclerosis. / Zanette, Giampietro; Forgione, Antonio; Manganotti, Paolo; Fiaschi, Antonio; Tamburin, Stefano.

In: Journal of the Neurological Sciences, Vol. 270, No. 1-2, 15.07.2008, p. 18-22.

Research output: Contribution to journalArticle

Zanette, Giampietro ; Forgione, Antonio ; Manganotti, Paolo ; Fiaschi, Antonio ; Tamburin, Stefano. / The effect of repetitive transcranial magnetic stimulation on motor performance, fatigue and quality of life in amyotrophic lateral sclerosis. In: Journal of the Neurological Sciences. 2008 ; Vol. 270, No. 1-2. pp. 18-22.
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