Abstract
The effect of 3 estrogen progestin combinations on biogenic amines in discrete brain areas of rats and mice has been investigated. With the exception of a significant decrease of brain 5 hydroxyindolacetic acid in the rats treated for 30 days with the combination norethynodrel + mestranol, no significant changes in the levels of serotonin, noradrenaline or dopamine in the rat brain were found following the administration of the compounds under study. On the other hand, in mice moderate but significant changes in the levels of serotonin, dopamine, noradrenaline and 5 hydroxyindolacetic acid were found in various brain areas depending on the estrogen progestin combination used. The potential importance of these effects for the contraceptive as well as for some central actions of these compounds is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 272-281 |
| Number of pages | 10 |
| Journal | Archives Internationales de Pharmacodynamie et de Therapie |
| Volume | 222 |
| Issue number | 2 |
| Publication status | Published - 1976 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
The effect of steroid contraceptives on the concentrations of brain monoamines in rats and mice. / Bernasconi, S.; Garattini, S.; Samanin, R.
In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 222, No. 2, 1976, p. 272-281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of steroid contraceptives on the concentrations of brain monoamines in rats and mice
AU - Bernasconi, S.
AU - Garattini, S.
AU - Samanin, R.
PY - 1976
Y1 - 1976
N2 - The effect of 3 estrogen progestin combinations on biogenic amines in discrete brain areas of rats and mice has been investigated. With the exception of a significant decrease of brain 5 hydroxyindolacetic acid in the rats treated for 30 days with the combination norethynodrel + mestranol, no significant changes in the levels of serotonin, noradrenaline or dopamine in the rat brain were found following the administration of the compounds under study. On the other hand, in mice moderate but significant changes in the levels of serotonin, dopamine, noradrenaline and 5 hydroxyindolacetic acid were found in various brain areas depending on the estrogen progestin combination used. The potential importance of these effects for the contraceptive as well as for some central actions of these compounds is discussed.
AB - The effect of 3 estrogen progestin combinations on biogenic amines in discrete brain areas of rats and mice has been investigated. With the exception of a significant decrease of brain 5 hydroxyindolacetic acid in the rats treated for 30 days with the combination norethynodrel + mestranol, no significant changes in the levels of serotonin, noradrenaline or dopamine in the rat brain were found following the administration of the compounds under study. On the other hand, in mice moderate but significant changes in the levels of serotonin, dopamine, noradrenaline and 5 hydroxyindolacetic acid were found in various brain areas depending on the estrogen progestin combination used. The potential importance of these effects for the contraceptive as well as for some central actions of these compounds is discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017116706&partnerID=8YFLogxK
M3 - Article
C2 - 984980
AN - SCOPUS:0017116706
VL - 222
SP - 272
EP - 281
JO - Archives Internationales de Pharmacodynamie et de Therapie
JF - Archives Internationales de Pharmacodynamie et de Therapie
SN - 0003-9780
IS - 2
ER -