The effect of time to sentinel lymph node biopsy on cutaneous melanoma survival

Cristina Fortes; Simona Mastroeni; Alessio Caggiati; Francesca Passarelli; Alba Zappalà; Maria Capuano; Riccardo Bono; Maurizio Nudo; Claudia Marino; Paola Michelozzi

doi:10.1016/j.amjsurg.2016.02.025

The effect of time to sentinel lymph node biopsy on cutaneous melanoma survival

Cristina Fortes, Simona Mastroeni, Alessio Caggiati, Francesca Passarelli, Alba Zappalà, Maria Capuano, Riccardo Bono, Maurizio Nudo, Claudia Marino, Paola Michelozzi

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Whether timing of sentinel lymph node biopsy (SLNB) in cutaneous melanoma improves survival is not yet clear. The aim of this study was to investigate if the timing of SLNB influences long-term melanoma mortality.

METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models.

RESULTS: After adjusting for sex, age, Breslow thickness, mitotic rate, ulceration, and histologic type, patients who underwent early SLNB (≤30 days) and resulted positive on final pathology had a 3 times decreased risk of melanoma mortality (hazard ratio = .29; 95%confidence interval = .11 to .77) in comparison to patients who underwent delayed SLNB (≥31 days) and resulted positive on final pathology.

CONCLUSIONS: Our findings suggest that early SLNB (≤30 days) improves melanoma survival.

Original language	English
Pages (from-to)	935-940
Number of pages	6
Journal	American Journal of Surgery
Volume	212
Issue number	5
DOIs	https://doi.org/10.1016/j.amjsurg.2016.02.025
Publication status	Published - Nov 2016

Keywords

Adult
Aged
Cause of Death
Cohort Studies
Confidence Intervals
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Male
Melanoma
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Prognosis
Proportional Hazards Models
Retrospective Studies
Sentinel Lymph Node
Sentinel Lymph Node Biopsy
Skin Neoplasms
Statistics, Nonparametric
Survival Analysis
Time Factors
Treatment Outcome
Journal Article

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The effect of time to sentinel lymph node biopsy on cutaneous melanoma survival. / Fortes, Cristina ; Mastroeni, Simona; Caggiati, Alessio; Passarelli, Francesca; Zappalà, Alba; Capuano, Maria; Bono, Riccardo; Nudo, Maurizio; Marino, Claudia; Michelozzi, Paola.

In: American Journal of Surgery, Vol. 212, No. 5, 11.2016, p. 935-940.

Research output: Contribution to journal › Article › peer-review

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abstract = "BACKGROUND: Whether timing of sentinel lymph node biopsy (SLNB) in cutaneous melanoma improves survival is not yet clear. The aim of this study was to investigate if the timing of SLNB influences long-term melanoma mortality.METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models.RESULTS: After adjusting for sex, age, Breslow thickness, mitotic rate, ulceration, and histologic type, patients who underwent early SLNB (≤30 days) and resulted positive on final pathology had a 3 times decreased risk of melanoma mortality (hazard ratio = .29; 95%confidence interval = .11 to .77) in comparison to patients who underwent delayed SLNB (≥31 days) and resulted positive on final pathology.CONCLUSIONS: Our findings suggest that early SLNB (≤30 days) improves melanoma survival.",

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AU - Fortes, Cristina

AU - Mastroeni, Simona

AU - Caggiati, Alessio

AU - Passarelli, Francesca

AU - Zappalà, Alba

AU - Capuano, Maria

AU - Bono, Riccardo

AU - Nudo, Maurizio

AU - Marino, Claudia

AU - Michelozzi, Paola

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N2 - BACKGROUND: Whether timing of sentinel lymph node biopsy (SLNB) in cutaneous melanoma improves survival is not yet clear. The aim of this study was to investigate if the timing of SLNB influences long-term melanoma mortality.METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models.RESULTS: After adjusting for sex, age, Breslow thickness, mitotic rate, ulceration, and histologic type, patients who underwent early SLNB (≤30 days) and resulted positive on final pathology had a 3 times decreased risk of melanoma mortality (hazard ratio = .29; 95%confidence interval = .11 to .77) in comparison to patients who underwent delayed SLNB (≥31 days) and resulted positive on final pathology.CONCLUSIONS: Our findings suggest that early SLNB (≤30 days) improves melanoma survival.

AB - BACKGROUND: Whether timing of sentinel lymph node biopsy (SLNB) in cutaneous melanoma improves survival is not yet clear. The aim of this study was to investigate if the timing of SLNB influences long-term melanoma mortality.METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models.RESULTS: After adjusting for sex, age, Breslow thickness, mitotic rate, ulceration, and histologic type, patients who underwent early SLNB (≤30 days) and resulted positive on final pathology had a 3 times decreased risk of melanoma mortality (hazard ratio = .29; 95%confidence interval = .11 to .77) in comparison to patients who underwent delayed SLNB (≥31 days) and resulted positive on final pathology.CONCLUSIONS: Our findings suggest that early SLNB (≤30 days) improves melanoma survival.

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