Abstract
BACKGROUND: Whether timing of sentinel lymph node biopsy (SLNB) in cutaneous melanoma improves survival is not yet clear. The aim of this study was to investigate if the timing of SLNB influences long-term melanoma mortality.
METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models.
RESULTS: After adjusting for sex, age, Breslow thickness, mitotic rate, ulceration, and histologic type, patients who underwent early SLNB (≤30 days) and resulted positive on final pathology had a 3 times decreased risk of melanoma mortality (hazard ratio = .29; 95%confidence interval = .11 to .77) in comparison to patients who underwent delayed SLNB (≥31 days) and resulted positive on final pathology.
CONCLUSIONS: Our findings suggest that early SLNB (≤30 days) improves melanoma survival.
| Original language | English |
|---|---|
| Pages (from-to) | 935-940 |
| Number of pages | 6 |
| Journal | American Journal of Surgery |
| Volume | 212 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 2016 |
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Keywords
- Adult
- Aged
- Cause of Death
- Cohort Studies
- Confidence Intervals
- Disease-Free Survival
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Melanoma
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Staging
- Prognosis
- Proportional Hazards Models
- Retrospective Studies
- Sentinel Lymph Node
- Sentinel Lymph Node Biopsy
- Skin Neoplasms
- Statistics, Nonparametric
- Survival Analysis
- Time Factors
- Treatment Outcome
- Journal Article
Cite this
The effect of time to sentinel lymph node biopsy on cutaneous melanoma survival. / Fortes, Cristina; Mastroeni, Simona; Caggiati, Alessio; Passarelli, Francesca; Zappalà, Alba; Capuano, Maria; Bono, Riccardo; Nudo, Maurizio; Marino, Claudia; Michelozzi, Paola.
In: American Journal of Surgery, Vol. 212, No. 5, 11.2016, p. 935-940.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of time to sentinel lymph node biopsy on cutaneous melanoma survival
AU - Fortes, Cristina
AU - Mastroeni, Simona
AU - Caggiati, Alessio
AU - Passarelli, Francesca
AU - Zappalà, Alba
AU - Capuano, Maria
AU - Bono, Riccardo
AU - Nudo, Maurizio
AU - Marino, Claudia
AU - Michelozzi, Paola
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2016/11
Y1 - 2016/11
N2 - BACKGROUND: Whether timing of sentinel lymph node biopsy (SLNB) in cutaneous melanoma improves survival is not yet clear. The aim of this study was to investigate if the timing of SLNB influences long-term melanoma mortality.METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models.RESULTS: After adjusting for sex, age, Breslow thickness, mitotic rate, ulceration, and histologic type, patients who underwent early SLNB (≤30 days) and resulted positive on final pathology had a 3 times decreased risk of melanoma mortality (hazard ratio = .29; 95%confidence interval = .11 to .77) in comparison to patients who underwent delayed SLNB (≥31 days) and resulted positive on final pathology.CONCLUSIONS: Our findings suggest that early SLNB (≤30 days) improves melanoma survival.
AB - BACKGROUND: Whether timing of sentinel lymph node biopsy (SLNB) in cutaneous melanoma improves survival is not yet clear. The aim of this study was to investigate if the timing of SLNB influences long-term melanoma mortality.METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models.RESULTS: After adjusting for sex, age, Breslow thickness, mitotic rate, ulceration, and histologic type, patients who underwent early SLNB (≤30 days) and resulted positive on final pathology had a 3 times decreased risk of melanoma mortality (hazard ratio = .29; 95%confidence interval = .11 to .77) in comparison to patients who underwent delayed SLNB (≥31 days) and resulted positive on final pathology.CONCLUSIONS: Our findings suggest that early SLNB (≤30 days) improves melanoma survival.
KW - Adult
KW - Aged
KW - Cause of Death
KW - Cohort Studies
KW - Confidence Intervals
KW - Disease-Free Survival
KW - Female
KW - Humans
KW - Kaplan-Meier Estimate
KW - Male
KW - Melanoma
KW - Middle Aged
KW - Neoplasm Invasiveness
KW - Neoplasm Staging
KW - Prognosis
KW - Proportional Hazards Models
KW - Retrospective Studies
KW - Sentinel Lymph Node
KW - Sentinel Lymph Node Biopsy
KW - Skin Neoplasms
KW - Statistics, Nonparametric
KW - Survival Analysis
KW - Time Factors
KW - Treatment Outcome
KW - Journal Article
U2 - 10.1016/j.amjsurg.2016.02.025
DO - 10.1016/j.amjsurg.2016.02.025
M3 - Article
C2 - 27266393
VL - 212
SP - 935
EP - 940
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 5
ER -