The effect of two different GH dosages on final height and bone geometry

Fiorenzo Lupi, Mauro Bozzola, Silvia Longhi, Giovanni Farello, Giorgio Radetti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Growth hormone (GH) has a strong positive influence on bone, stimulating both bone elongation and increase in size. The aim of the study was to compare the effect of two different GH dosages on final height and bone geometry in two groups of GH-deficient children. Methods: We evaluated 121 children (86 m, 35f). Group 1 (77 patients) treated with GH at a mean dose of 0.16 mg/kg/week and group 2 (44 patients) at 0.3 mg/kg/week. Bone geometry was evaluated at final height from a digitalized X-ray of the left hand considering the following parameters: metacarpal index (MI), cross-sectional area (CSA), cortical area (CA) and medullary area (MA). Results: At baseline, group 2 was shorter than group 1 (-1.54 vs -1.01 SDS; p <0.005), while at final height there was no difference. Height gain was significantly greater in group 2 than in group 1 (1.62 vs 1.13 SDS; p <0.001). Bone geometry: MI was significantly greater in group 2 (0.62 vs 0.55; p <0.001) as well as CA (46.87 vs 42.69 cm2; p <0.005), while MA was significantly lower in group 2 (8.48 vs 11.65 cm2; p <0.002). Conclusion: Higher GH doses elicit a significantly greater statural gain and a greater bone cortical area.

Original languageEnglish
Article number212
JournalItalian Journal of Pediatrics
Volume42
Issue number1
DOIs
Publication statusPublished - Jan 15 2016

Keywords

  • Bone geometry
  • Children
  • Final height
  • GH dosage
  • GH treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'The effect of two different GH dosages on final height and bone geometry'. Together they form a unique fingerprint.

Cite this