EFFETTO DELLA VILOXAZINA SUI LIVELLI EMATICI DI OXCARBAZEPINA E DEI RELATIVI METABOLITI

Translated title of the contribution: The effect of viloxazine on the serum levels of Oxcarbazepine and its metabolites

F. Pisani, A. Fazio, C. Artesi, M. Russo, R. Trio, G. Oteri, B. Xiao, E. Perucca, R. Di Perri

Research output: Contribution to journalArticlepeer-review

Abstract

Addition of the antidepressant drug Viloxazine (VLX) to six epileptic patients stabilized on oxcarbazepine (OXCZ) therapy was evaluated with respect to serum levels of OXCZ and its two major metabolites MHD and DHD. The study was carried out in a randomized, double-blind, placebo-controlled design. Administration of VLX resulted in an increase in MHD levels by 11% on average and a concomitant decrease in plasma DHD by 31% on average. Steady-state levels of OXCZ remained stable throughout the study. These changes in plasma OXCZ metabolites were not associated with clinical manifestations.

Translated title of the contributionThe effect of viloxazine on the serum levels of Oxcarbazepine and its metabolites
Original languageItalian
Pages (from-to)157-158
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number82-83
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Clinical Neurology

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