The effect on the fatigue strength of bone cement of adding sodium fluoride

C. Minari, M. Baleani, L. Cristofolini, F. Baruffaldi

Research output: Contribution to journalArticlepeer-review


New bone cements that include several additives are currently being investigated and tested. One such additive is sodium fluoride (NaF), which promotes bone formation, facilitating implant integration and success. The influence of NaF on the fatigue performance of the cement as used in biomedical applications was tested in this paper. In fact fatigue failure of the cement mantle is a major factor limiting the longevity of a cemented implant. An experimental bone cement with added NaF (12 wt%) was investigated. The fatigue strength of the novel bone cement was evaluated in comparison with the cement without additives; fatigue tests were conducted according to current standards. The load levels were arranged based on a validated, statistically based optimization algorithm. The curve of stress against number of load cycles and the endurance limit were obtained and compared for both formulations. The results showed that the addition of NaF (12 wt%) to polymethylmethacrylate (PMMA) bone cement does not affect the fatigue resistance of the material. Sodium fluoride can safely be added to the bone cement without altering the fatigue performance of the PMMA bone cement.

Original languageEnglish
Pages (from-to)251-253
Number of pages3
JournalProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Issue number2
Publication statusPublished - 2001


  • Acrylic cement
  • Additives
  • Fatigue
  • Sodium fluoride

ASJC Scopus subject areas

  • Biomedical Engineering
  • Mechanical Engineering


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