The effectiveness of FloSeal® matrix hemostatic agent in thyroid surgery: A prospective, randomized, control study

Mario Testini, Rinaldo Marzaioli, Germana Lissidini, Agostino Lippolis, Francesco Logoluso, Angela Gurrado, Domenica Lardo, Elisabetta Poli, Giuseppe Piccinni

Research output: Contribution to journalArticle

Abstract

The objective of this study was to compare the effectiveness of FloSeal® matrix hemostatic agent with hemostatic surgical procedures and Tabotamp® in thyroid surgery. One hundred fifty-five consecutive total thyroidectomy patients were recruited at our institution between January 2005 and December 2007. Exclusion criteria were applied. Patients were randomized to one of three hemostatic approaches: 49 received surgical procedures only, and 52 received oxidized regenerated cellulose patch (Tabotamp Fibrillar 2.5∈×∈5 cm) and 54 FloSeal (5,000 U/5 mL). The same surgeon performed all operations. Mean operating time was reduced in the FloSeal group (105 min) vs. surgical (133 min, p∈=∈0.02) and vs. Tabotamp (122 min, p∈=∈0.0003). Also, wound drain removal occurred earlier with FloSeal (p∈=∈0.006 vs. surgical; p∈=∈0.008 vs. Tabotamp) resulting in shorter postoperative hospital stay in the FloSeal group (p∈=∈0.02 vs. surgical; p∈=∈0.002 vs. Tabotamp). FloSeal matrix is an effective additional agent to conventional haemostatic procedures in thyroid surgery.

Original languageEnglish
Pages (from-to)837-842
Number of pages6
JournalLangenbeck's Archives of Surgery
Volume394
Issue number5
DOIs
Publication statusPublished - Sep 2009

Keywords

  • FloSeal
  • Hemorrhagic complication
  • Hemostatic agent
  • Tabotamp
  • Thyroidectomy

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

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