TY - JOUR
T1 - The effectiveness of FloSeal® matrix hemostatic agent in thyroid surgery
T2 - A prospective, randomized, control study
AU - Testini, Mario
AU - Marzaioli, Rinaldo
AU - Lissidini, Germana
AU - Lippolis, Agostino
AU - Logoluso, Francesco
AU - Gurrado, Angela
AU - Lardo, Domenica
AU - Poli, Elisabetta
AU - Piccinni, Giuseppe
PY - 2009/9
Y1 - 2009/9
N2 - The objective of this study was to compare the effectiveness of FloSeal® matrix hemostatic agent with hemostatic surgical procedures and Tabotamp® in thyroid surgery. One hundred fifty-five consecutive total thyroidectomy patients were recruited at our institution between January 2005 and December 2007. Exclusion criteria were applied. Patients were randomized to one of three hemostatic approaches: 49 received surgical procedures only, and 52 received oxidized regenerated cellulose patch (Tabotamp Fibrillar 2.5∈×∈5 cm) and 54 FloSeal (5,000 U/5 mL). The same surgeon performed all operations. Mean operating time was reduced in the FloSeal group (105 min) vs. surgical (133 min, p∈=∈0.02) and vs. Tabotamp (122 min, p∈=∈0.0003). Also, wound drain removal occurred earlier with FloSeal (p∈=∈0.006 vs. surgical; p∈=∈0.008 vs. Tabotamp) resulting in shorter postoperative hospital stay in the FloSeal group (p∈=∈0.02 vs. surgical; p∈=∈0.002 vs. Tabotamp). FloSeal matrix is an effective additional agent to conventional haemostatic procedures in thyroid surgery.
AB - The objective of this study was to compare the effectiveness of FloSeal® matrix hemostatic agent with hemostatic surgical procedures and Tabotamp® in thyroid surgery. One hundred fifty-five consecutive total thyroidectomy patients were recruited at our institution between January 2005 and December 2007. Exclusion criteria were applied. Patients were randomized to one of three hemostatic approaches: 49 received surgical procedures only, and 52 received oxidized regenerated cellulose patch (Tabotamp Fibrillar 2.5∈×∈5 cm) and 54 FloSeal (5,000 U/5 mL). The same surgeon performed all operations. Mean operating time was reduced in the FloSeal group (105 min) vs. surgical (133 min, p∈=∈0.02) and vs. Tabotamp (122 min, p∈=∈0.0003). Also, wound drain removal occurred earlier with FloSeal (p∈=∈0.006 vs. surgical; p∈=∈0.008 vs. Tabotamp) resulting in shorter postoperative hospital stay in the FloSeal group (p∈=∈0.02 vs. surgical; p∈=∈0.002 vs. Tabotamp). FloSeal matrix is an effective additional agent to conventional haemostatic procedures in thyroid surgery.
KW - FloSeal
KW - Hemorrhagic complication
KW - Hemostatic agent
KW - Tabotamp
KW - Thyroidectomy
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U2 - 10.1007/s00423-009-0497-5
DO - 10.1007/s00423-009-0497-5
M3 - Article
C2 - 19421770
AN - SCOPUS:68549132419
VL - 394
SP - 837
EP - 842
JO - Langenbecks Archiv fur Chirurgie
JF - Langenbecks Archiv fur Chirurgie
SN - 0023-8236
IS - 5
ER -