The effects of 2-(α-tenoyl) thiopropionylglycine (TTPG) on human lung mucus

M. C. Morale, A. Fiumara, A. Bousquet, M. Matera, V. Guarcello, V. Rizza

Research output: Contribution to journalArticle

Abstract

2-(α-Tenoyl)-thiopropionylglycine (TTPG) was tested for its mucolytic activity on mucus specimens from human lungs. Our data demonstrate that a methoxydalbergione amount of mucus is solubilized in the presence of TTPG; this aspect is more evident when rat liver microsomes are incubated together with lung mucus and TTPG. Furthermore our data demonstrate the presence of thioesterase activity associated with liver, lung, kidney and brain microsomes capable of hydrolysing TTPG and thus liberating free thiol groups. Further studies are in progress to characterize the microsomal thioester activity as well as its probable role in regulating the viscosity of mucus.

Original languageEnglish
Pages (from-to)231-235
Number of pages5
JournalInternational Journal of Tissue Reactions
Volume5
Issue number2
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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    Morale, M. C., Fiumara, A., Bousquet, A., Matera, M., Guarcello, V., & Rizza, V. (1983). The effects of 2-(α-tenoyl) thiopropionylglycine (TTPG) on human lung mucus. International Journal of Tissue Reactions, 5(2), 231-235.