Abstract
Chronic administration of dihydroergotoxine, at the two doses of 2.5 mg/kg and 5 mg/kg decreases the binding of dopamine 3H-agonists to striatal membranes. By contrast the binding of dopamine 3H-antagonists is decreased in the animals treated with the higher dose and increased in those treated with the lower one. In old rats, in which a partial loss of both 3H-antagonist and 3H-agonist binding sites is observed, the DHT treatment confirms to increase the binding of 3H-antagonists, without affecting that of 3H-agonists. Thus, aging and ergot alkaloids seem to discrimate between DA-agonist and DA-antagonist receptor sites suggesting that this receptors are separate entityes.
| Original language | English |
|---|---|
| Pages (from-to) | 967-978 |
| Number of pages | 12 |
| Journal | Pharmacological Research Communications |
| Volume | 18 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1986 |
Keywords
- H-spiperone
- HNPropyl-Norapomorphine
- Aging brain
- Dihydroergotoxine
- Dopamine receptors
- Ergot alkaloids
ASJC Scopus subject areas
- Pharmacology
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Ferretti, C., Blengio, M., Eva, C., Ghi, P., Bosco, M. C., & Portaleone, P. (1986). The effects of a long term dihydroergotoxine treatment on agonist and antagonist striatal dopamine binding sites are dose and age related. Pharmacological Research Communications, 18(10), 967-978. https://doi.org/10.1016/0031-6989(86)90099-8