Abstract
Chronic administration of dihydroergotoxine, at the two doses of 2.5 mg/kg and 5 mg/kg decreases the binding of dopamine 3H-agonists to striatal membranes. By contrast the binding of dopamine 3H-antagonists is decreased in the animals treated with the higher dose and increased in those treated with the lower one. In old rats, in which a partial loss of both 3H-antagonist and 3H-agonist binding sites is observed, the DHT treatment confirms to increase the binding of 3H-antagonists, without affecting that of 3H-agonists. Thus, aging and ergot alkaloids seem to discrimate between DA-agonist and DA-antagonist receptor sites suggesting that this receptors are separate entityes.
Original language | English |
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Pages (from-to) | 967-978 |
Number of pages | 12 |
Journal | Pharmacological Research Communications |
Volume | 18 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1986 |
Keywords
- H-spiperone
- HNPropyl-Norapomorphine
- Aging brain
- Dihydroergotoxine
- Dopamine receptors
- Ergot alkaloids
ASJC Scopus subject areas
- Pharmacology