TY - JOUR
T1 - The effects of anandamide on memory consolidation in mice involve both D1 and D2 dopamine receptors
AU - Castellano, C.
AU - Cabib, S.
AU - Palmisano, A.
AU - Di Marzo, V.
AU - Puglisi-Allegra, S.
PY - 1997
Y1 - 1997
N2 - Post-training administration of anandamide (1.5, 3, 6 mg/kg) dose- dependently impairs the retention of an inhibitory avoidance response in mice. The effects on retention performance induced by the drug appear to be due to an effect on memory consolidation, as they were observed when drugs were given at short, but not long, periods of time after training, i.e. when the memory trace was susceptible to modulation. Pretreatment with either selective D1 or D2 dopamine (DA) receptor agonists, SKF 38393 and quinpirole, at doses that were ineffective when given alone (5 and 0.25 mg/kg, respectively), antagonized the effects of anandamide on memory consolidation, suggesting that D1 and D2 receptors are similarly involved in the effects of anandamide on memory consolidation. These results are discussed in terms of a possible inverse relationship between the modulation of memory processes by endogenous cannabinoid and DA systems.
AB - Post-training administration of anandamide (1.5, 3, 6 mg/kg) dose- dependently impairs the retention of an inhibitory avoidance response in mice. The effects on retention performance induced by the drug appear to be due to an effect on memory consolidation, as they were observed when drugs were given at short, but not long, periods of time after training, i.e. when the memory trace was susceptible to modulation. Pretreatment with either selective D1 or D2 dopamine (DA) receptor agonists, SKF 38393 and quinpirole, at doses that were ineffective when given alone (5 and 0.25 mg/kg, respectively), antagonized the effects of anandamide on memory consolidation, suggesting that D1 and D2 receptors are similarly involved in the effects of anandamide on memory consolidation. These results are discussed in terms of a possible inverse relationship between the modulation of memory processes by endogenous cannabinoid and DA systems.
KW - Anandamide
KW - Cannabinoids
KW - Dopamine
KW - Inhibitory avoidance
KW - Mouse
UR - http://www.scopus.com/inward/record.url?scp=0031459576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031459576&partnerID=8YFLogxK
U2 - 10.1097/00008877-199712000-00005
DO - 10.1097/00008877-199712000-00005
M3 - Article
C2 - 9832956
AN - SCOPUS:0031459576
VL - 8
SP - 707
EP - 712
JO - Behavioural Pharmacology
JF - Behavioural Pharmacology
SN - 0955-8810
IS - 8
ER -