The effects of anandamide on memory consolidation in mice involve both D1 and D2 dopamine receptors

C. Castellano, S. Cabib, A. Palmisano, V. Di Marzo, S. Puglisi-Allegra

Research output: Contribution to journalArticlepeer-review

Abstract

Post-training administration of anandamide (1.5, 3, 6 mg/kg) dose- dependently impairs the retention of an inhibitory avoidance response in mice. The effects on retention performance induced by the drug appear to be due to an effect on memory consolidation, as they were observed when drugs were given at short, but not long, periods of time after training, i.e. when the memory trace was susceptible to modulation. Pretreatment with either selective D1 or D2 dopamine (DA) receptor agonists, SKF 38393 and quinpirole, at doses that were ineffective when given alone (5 and 0.25 mg/kg, respectively), antagonized the effects of anandamide on memory consolidation, suggesting that D1 and D2 receptors are similarly involved in the effects of anandamide on memory consolidation. These results are discussed in terms of a possible inverse relationship between the modulation of memory processes by endogenous cannabinoid and DA systems.

Original languageEnglish
Pages (from-to)707-712
Number of pages6
JournalBehavioural Pharmacology
Volume8
Issue number8
DOIs
Publication statusPublished - 1997

Keywords

  • Anandamide
  • Cannabinoids
  • Dopamine
  • Inhibitory avoidance
  • Mouse

ASJC Scopus subject areas

  • Pharmacology
  • Neuroscience(all)

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