The effects of atorvastatin treatment on the mean platelet volume and red cell distribution width in patients with dyslipoproteinemia and comparison with plasma atherogenicity indicators-A pilot study

Marek Kucera, David Balaz, Peter Kruzliak, Rachele Ciccocioppo, Stanislav Oravec, Luis Rodrigo, Anthony Zulli, Eva Hirnerova, Peter Sabaka, Andrea Komornikova, Jan Sabo, Peter Slezak, Ludovit Gaspar

Research output: Contribution to journalArticle

Abstract

Objectives: The mean platelet volume (MPV) and red cell distribution width (RDW) have recently arisen interest because of their association with an increased cardiovascular risk. The aim of our study was, therefore, to determine whether an association exists between MPV, RDW and lipoprotein sub-fractions, and to show the impact of statin therapy on these new possible biomarkers of atherosclerotic risk. Design and methods: A cohort of 40 patients with hypercholesterolaemia (29 females, mean age 62.9. ±. 9. years), without previous hypolipidaemic treatment were enrolled. The patients were treated with atorvastatin 40. mg/day for 12. weeks. Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density cholesterol (HDL-C), triglycerides (TG), LDL-C sub-fractions [large LDL-C 1-2 and small dense (sd)-LDL-C 3-7], apolipoproteins (apoA1, apoB), apoB/apoA1 ratio, atherogenic index of plasma (AIP), haematological parameters (including MPV, RDW) and safety parameters (renal, hepatic) were measured before and after 12. weeks of atorvastatin treatment. Results: At baseline, a strong correlation between HDL-C, TG, sd-LDL-C, apoB, apoB/apoA1, and AIP with MPV (. r=. -. 0.55, p

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalClinical Biochemistry
Volume48
Issue number9
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Atherogenic dyslipidaemia
  • Atorvastatin
  • Dense LDL
  • Mean platelet volume
  • Red cell distribution width
  • Small

ASJC Scopus subject areas

  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'The effects of atorvastatin treatment on the mean platelet volume and red cell distribution width in patients with dyslipoproteinemia and comparison with plasma atherogenicity indicators-A pilot study'. Together they form a unique fingerprint.

  • Cite this

    Kucera, M., Balaz, D., Kruzliak, P., Ciccocioppo, R., Oravec, S., Rodrigo, L., Zulli, A., Hirnerova, E., Sabaka, P., Komornikova, A., Sabo, J., Slezak, P., & Gaspar, L. (2015). The effects of atorvastatin treatment on the mean platelet volume and red cell distribution width in patients with dyslipoproteinemia and comparison with plasma atherogenicity indicators-A pilot study. Clinical Biochemistry, 48(9), 557-561. https://doi.org/10.1016/j.clinbiochem.2015.02.010