Effetti del peptide natriuretico atriale sulla funzione ventricolare sinistra in soggetti con scompenso cardiaco.

Translated title of the contribution: The effects of atrial natriuretic peptide on left ventricular function in subjects with heart failure

C. Indolfi, F. Piscione, M. Volpe, G. Lembo, P. De Campora, E. Russolillo, V. Ambrosini, M. Condorelli, M. Chiariello

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of atrial natriuretic peptide (ANP) infusion was evaluated in 11 patients with congestive heart failure undergoing cardiac catheterization. Data were obtained at rest and during steady-state phase of alpha-human (1-28) ANP infusion (1 microgram/kg bolus dose, 0.1 microgram/kg/min iv for 30 min). Mean blood pressure decreased from 104 +/- 20 to 89 +/- 21 mmHg (p less than 0.05) 15 min after ANP infusion, as well as left ventricular end-diastolic pressure (from 27 +/- 6 to 14 +/- 11 mmHg, p less than 0.05) and wedge pressure (from 22 +/- 5 to 13 +/- 7 mmHg, p less than 0.05). Left ventricular ejection fraction increased significantly after ANP infusion from 39 +/- 7 to 47 +/- 2%, p less than 0.01. The ANP infusion significantly increased cardiac output from 4.9 +/- 0.8 to 5.8 +/- 1.41/min, p less than 0.05, and decreased the relaxation constant from 69 +/- 17 to 48 +/- 18, p less than 0.05. These results demonstrate that in patients with congestive heart failure ANP infusion decreased wedge pulmonary pressure, left ventricular end-diastolic pressure and increased cardiac output and left ventricular ejection fraction.

Translated title of the contributionThe effects of atrial natriuretic peptide on left ventricular function in subjects with heart failure
Original languageItalian
Pages (from-to)351-356
Number of pages6
JournalCardiologia
Volume36
Issue number5
Publication statusPublished - May 1991

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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