The effects of biliopancreatic diversion on type 2 diabetes mellitus in patients with mild obesity (BMI 30-35 kg/m 2) and simple overweight (BMI 25-30 kg/m 2): A prospective controlled study

Nicola Scopinaro, Giovanni F. Adami, Francesco S. Papadia, Giovanni Camerini, Flavia Carlini, Lucia Briatore, Gabriele D'Alessandro, Corrado Parodi, Andrea Weiss, Gabriella Andraghetti, Mariafrancesca Catalano, Renzo Cordera

Research output: Contribution to journalArticle

Abstract

Background: Beneficial effects of BPD on T2DM in BMI >35 kg/m 2 patients are far better than those in patients with BMI 25-35. This study was aimed at investigating if a similar difference exists between patients with mild obesity (OB, BMI 30-35) or simple overweight (OW, BMI 25-30). Methods: Fifteen OB (six M) and 15 OW (13 M), diabetic for ≥3 years, with HbA1c ≥7.5% despite medical therapy, underwent BPD. OB/OW: age 55.1±8.0/57.8±6.7 years, BMI 33.1±1.5/28.0±1.3 kg/m 2, diabetes duration 11.6±8.0/11.1±6.1 years, insulin therapy 4/8 p. FSG and HbA1c were determined preoperatively and up to 2 years. Insulin resistance and beta-cell function were explored by means of HOMA-IR and IVGTT (AIR). Thirty-eight diabetic patients on medical therapy served as controls. Results: Mean BMI stabilized around 27 since the 4th month in OB, and 24 since 1st month in OW. FSG in OB/OW preop, 1, 12, 24 months: 234±76/206±62 mg/dL, 154±49/176±75, 131±32/167±48, 134±41/154±41 (cross-sectional n.s. at all times); HbA1c: 9.5±1.6/9.1±1.3, 7.3±1.1/7. 3±1.2, 5.9±0.6/7.1±1.1 (p

Original languageEnglish
Pages (from-to)880-888
Number of pages9
JournalObesity Surgery
Volume21
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Beta-cell function
  • Biliopancreatic diversion
  • Diabetes surgery
  • Insulin resistance
  • Islet function
  • Metabolic surgery
  • Surgery
  • Type 2 diabetes

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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    Scopinaro, N., Adami, G. F., Papadia, F. S., Camerini, G., Carlini, F., Briatore, L., D'Alessandro, G., Parodi, C., Weiss, A., Andraghetti, G., Catalano, M., & Cordera, R. (2011). The effects of biliopancreatic diversion on type 2 diabetes mellitus in patients with mild obesity (BMI 30-35 kg/m 2) and simple overweight (BMI 25-30 kg/m 2): A prospective controlled study. Obesity Surgery, 21(7), 880-888. https://doi.org/10.1007/s11695-011-0407-0