The effects of calcitriol and nicotinamide on residual pancreatic β-cell function in patients with recent-onset Type 1 diabetes (IMDIAB XI)

D. Pitocco, A. Crinò, E. Di Stasio, S. Manfrini, C. Guglielmi, S. Spera, G. Beretta Anguissola, N. Visalli, C. Suraci, M. C. Matteoli, I. P. Patera, M. G. Cavallo, C. Bizzarri, P. Pozzilli

Research output: Contribution to journalArticle

Abstract

Background: A number of recent studies underline the importance of vitamin D in the pathogenesis of Type 1 diabetes (T1D). Aims: The aim of this study was to investigate whether supplementation with the active form of vitamin D (calcitriol) in subjects with recent-onset T1D protects residual pancreatic β-cell function and improves glycaemic control (HbA1c and insulin requirement). Methods: In this open-label randomized trial, 70 subjects with recent-onset T1D, mean age 13.6 years ± 7.6 SD were randomized to calcitriol (0.25 μg on alternate days) or nicotinamide (25 mg/kg daily) and followed up for 1 year. Intensive insulin therapy was implemented with three daily injections of regular insulin + NPH insulin at bedtime. Results: No significant differences were observed between calcitriol and nicotinamide groups in respect of baseline/stimulated C-peptide or HbA1c 1 year after diagnosis, but the insulin dose at 3 and 6 months was significantly reduced in the calcitriol group. Conclusions: At the dosage used, calcitriol has a modest effect on residual pancreatic β-cell function and only temporarily reduces the insulin dose.

Original languageEnglish
Pages (from-to)920-923
Number of pages4
JournalDiabetic Medicine
Volume23
Issue number8
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Calcitriol
  • Nicotinamide
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Pitocco, D., Crinò, A., Di Stasio, E., Manfrini, S., Guglielmi, C., Spera, S., Beretta Anguissola, G., Visalli, N., Suraci, C., Matteoli, M. C., Patera, I. P., Cavallo, M. G., Bizzarri, C., & Pozzilli, P. (2006). The effects of calcitriol and nicotinamide on residual pancreatic β-cell function in patients with recent-onset Type 1 diabetes (IMDIAB XI). Diabetic Medicine, 23(8), 920-923. https://doi.org/10.1111/j.1464-5491.2006.01921.x