The effects of childhood maltreatment on brain structure in adults with eating disorders

Alessio Maria Monteleone, Palmiero Monteleone, Fabrizio Esposito, Anna Prinster, Valeria Ruzzi, Antonietta Canna, Marco Aiello, Francesco Di Salle, Mario Maj

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Childhood maltreatment is a non-specific risk factor for eating disorders (EDs). However, so far, no study has assessed the impact of childhood maltreatment on brain structure of adults with EDs. Therefore, we investigated brain area volumes and fibre tract integrity of childhood maltreated (Mal) and non-maltreated (noMal) patients with EDs. Methods: Thirty-six ED women and 16 healthy women underwent an MRI scan, including acquisition of a diffusion tensor imaging (DTI) sequence and a high-resolution T1-weighted scan. ED participants were classified as Mal (18 patients) or noMal (18 patients) according to their childhood exposure to traumatic events assessed by the Childhood Trauma Questionnaire (CTQ). Results: Significantly reduced grey matter volume was detected in the right paracentral lobule and in the left inferior temporal gyrus of Mal patients. DTI analyses revealed reduced white matter integrity in the corpus callosum, internal capsule, posterior thalamic radiation, longitudinal fasciculus and corona radiata of Mal patients. Negative correlations emerged between white/grey matter changes and CTQ emotional and physical neglect scores. Conclusions: These results show that childhood trauma affects the integrity of brain structures modulating brain processes, such as reward, taste and body image perception, which play a fundamental role in the psychopathology of EDs.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalWorld Journal of Biological Psychiatry
DOIs
Publication statusAccepted/In press - Nov 15 2017

Keywords

  • Anorexia nervosa
  • bulimia nervosa
  • childhood trauma
  • eating disorders
  • MRI

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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