The effects of cyclophosphamide given for 18 weeks in small daily doses on CFU-(S), CFU-(C) and CFU-(E) content in mice bone marrow and spleen were studied. In the bone marrow, after an initial drop, the stem cell content rises above the normal values and remains there throughout a long period. In the spleen the stem cell content shows an initial several fold increase followed by a steady decline. It seems possible that this behaviour reflects a compensative effect to the toxic action of the drug at more differentiated levels of the haemopoietic cells.
|Number of pages||7|
|Journal||Scandinavian Journal of Haematology|
|Publication status||Published - 1977|
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