The effects of chronic administration of cyclophosphamide on haemopoietic stem cells

I. M. Pannacciulli, G. Massa, A. G. Saviane, G. Bianchi, G. V. Bogliolo, R. Ghio

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of cyclophosphamide given for 18 weeks in small daily doses on CFU-(S), CFU-(C) and CFU-(E) content in mice bone marrow and spleen were studied. In the bone marrow, after an initial drop, the stem cell content rises above the normal values and remains there throughout a long period. In the spleen the stem cell content shows an initial several fold increase followed by a steady decline. It seems possible that this behaviour reflects a compensative effect to the toxic action of the drug at more differentiated levels of the haemopoietic cells.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalScandinavian Journal of Haematology
Volume19
Issue number2
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Hematology

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