Effetti del trattamento cronico con cilazapril sul tono vasomotorio simpatico: studio con analisi spettrale della variabilità pressoria.

Translated title of the contribution: The effects of chronic cilazapril treatment on sympathetic vasomotor tonus: a spectral analysis study of pressure variability

M. Pagani, D. Lucini, P. Pizzinelli, V. Brera, D. Sommariva, R. Di Michele, A. Malliani

Research output: Contribution to journalArticlepeer-review

Abstract

Animal experiments suggest that an important component of the antihypertensive effects of ACE inhibitors might derive from an inhibition of the sympathetic vasomotor tone. We addressed this problem on 22 mildly hypertensive subjects (48 +/- 2 years; arterial pressure 151 +/- 3/95 +/- 1 mmHg), in whom sympathetic vasomotor tone was non invasively inferred by the power of the low frequency component (0.1 Hz) of the spontaneous oscillations of systolic arterial pressure (LFSAP), during placebo and after 4 weeks of treatment with a new ACE inhibitor, cilazapril, 5 mg per os oid. LFSAP was computed at rest and during physical (active orthostatism) and mental (computerized attentional test and mental arithmetic) stimuli capable of enhancing sympathetic drive. Cilazapril treatment reduced resting arterial pressure to 128 +/- 3/80 +/- 2 mmHg, without affecting heart rate (78 +/- 2 and 74 +/- 2 b/min, respectively). The increases in LFSAP produced by standing were significantly greater during placebo than during active treatment (delta LFSAP = 10 +/- 3 and 5 +/- 2 mmHg2, respectively). These data suggest that an important reduction of sympathetic vasomotor tone accompanies the antihypertensive effects of chronic ACE-inhibitor treatment.

Translated title of the contributionThe effects of chronic cilazapril treatment on sympathetic vasomotor tonus: a spectral analysis study of pressure variability
Original languageItalian
Pages (from-to)149-156
Number of pages8
JournalCardiologia
Volume38
Issue number3
Publication statusPublished - Mar 1993

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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