The effects of chronic hypoxia on left ventricular peak filling rate evaluated by equilibrium radionuclide angiocardiography

C. L. Maini, R. Antonelli Incalzi, M. G. Bonetti, G. Valle

Research output: Contribution to journalArticle

Abstract

Left ventricular peak filling rate (PFR) was measured by equilibrium radionuclide angiocardiography (ERNA) in 15 patients with Stage II stabilized chronic respiratory failure (CRF) without evidence of coexisting heart diseases and in 18 patients with coronary artery disease (CAD) without myocardial infarction. The study was designed to assess the effects of severe hypoxia and of ischaemia on the calcium-dependent early diastolic filling. PFR was found to be impaired in both groups of patients (mean = 1.72 EDVs-1and s.e.m. = 0.07 in CAD; mean = 2.35 EDVs-1and s.e.m. = 0.14 in CRF) but significantly less (p <0.001) in CRF patients while the left ventricular ejection fraction (LVEF) values were not significantly different between the two groups (mean = 60.0% and s.e.m. = 1.4 in CAD; mean = 62.0% and s.e.m. = 1.6 in CRF). As PFR is known to be a sensitive index of left ventricular performance the results obtained in this human model are consistent with findings obtained in animal models suggesting tha t hypoxia is less efficient than ischaemia in depressing left ventricular function.

Original languageEnglish
Pages (from-to)705-711
Number of pages7
JournalNuclear Medicine Communications
Volume7
Issue number9
Publication statusPublished - 1986

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Gated Blood-Pool Imaging
Respiratory Insufficiency
Coronary Artery Disease
Ischemia
Left Ventricular Function
Stroke Volume
Heart Diseases
Animal Models
Calcium
Hypoxia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

The effects of chronic hypoxia on left ventricular peak filling rate evaluated by equilibrium radionuclide angiocardiography. / Maini, C. L.; Antonelli Incalzi, R.; Bonetti, M. G.; Valle, G.

In: Nuclear Medicine Communications, Vol. 7, No. 9, 1986, p. 705-711.

Research output: Contribution to journalArticle

Maini, C. L. ; Antonelli Incalzi, R. ; Bonetti, M. G. ; Valle, G. / The effects of chronic hypoxia on left ventricular peak filling rate evaluated by equilibrium radionuclide angiocardiography. In: Nuclear Medicine Communications. 1986 ; Vol. 7, No. 9. pp. 705-711.
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