The effects of deoxyspergualin on the development of diabetes in diabetes-prone BB rats

F. Nicoletti, P. L. Meroni, R. Di Marco, S. Grasso, W. Barcellini, M. O. Borghi, M. Lunetta, L. Mughini, R. Menta, H. U. Schorlemmer, C. Zanussi

Research output: Contribution to journalArticle

Abstract

The effects of the administration of the recently discovered immunosuppressant 15-Deoxyspergualin (DSP) on the development of insulin-dependent diabetes mellitus (IDDM) in diabetes-prone BB rats were studied. The data show that 2 mg/kg body weight DSP, administered six times a week from the 30th day up to the 105th day of age, significantly reduced the incidence of diabetes in diabetes-prone BB rats as compared with the PBS-injected controls. The drug was also able to reduce the signs of pancreatic insulitis and the percentages of W3/25+ and OX6+ splenocytes. Interruption of the treatment resulted in a later onset of diabetes in a high percentage of animals within 41 days. These findings suggest that 15-DSP may temporarily reverse the pathogenic mechanisms leading to beta cell destruction and autoimmune diabetes in a well-known experimental model of human insulin-dependent diabetes mellitus.

Original languageEnglish
Pages (from-to)415-420
Number of pages6
JournalScandinavian Journal of Immunology
Volume36
Issue number3
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Immunology

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    Nicoletti, F., Meroni, P. L., Di Marco, R., Grasso, S., Barcellini, W., Borghi, M. O., Lunetta, M., Mughini, L., Menta, R., Schorlemmer, H. U., & Zanussi, C. (1992). The effects of deoxyspergualin on the development of diabetes in diabetes-prone BB rats. Scandinavian Journal of Immunology, 36(3), 415-420.