The effects of flumazenil on focal, electroinduced after-discharge in rabbits

Paola Bo, Debora Soragna, Enrico Marchioni, Andrea Albergati, Elisa Candeloro, Faustino Savoldi

Research output: Contribution to journalArticle

Abstract

1. The anticonvulsive efficacy of flumazenil 10 mg/kg i.v., a BDZ antagonist, was studied in two models of experimental epilepsy electrically induced. 2. The EEG after-discharge, which was induced by the electrical stimulation of selected brain regions [(notably the dorsal hippocampus (Hip) and the amygdala (CAm)] was evaluated in rabbits pre- and post-drug administration. 3. In the animals submitted to electrical stimulation of the amygdala, flumazenil exerted a protective action, thereby inducing an increase in the after-discharge threshold and/or a decrease in after- discharge duration. 4. In the animals submitted to electrical stimulation of the hippocampus, flumazenil did not induced changes statistically significant. 5. Finally, the paper discusses the two possible mechanisms of action of flumazenil (a 'per se' partial BDZ activity and/or a BDZ agonistic activity, which displaces the inverse agonist-like ligand) and the differencies in GABA distribution in the hippocampus and the amygdala.

Original languageEnglish
Pages (from-to)199-209
Number of pages11
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1998

Keywords

  • BDZ-receptors
  • EEG
  • Epilepsy
  • Flumazenil
  • Rabbits

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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