The effects of gabapentin on different ligand- and voltage-gated currents in isolated cortical neurons

Alessandro Stefani, Francesca Spadoni, Patrizia Giacomini, Franco Lavaroni, Giorgio Bernardi

Research output: Contribution to journalArticle

Abstract

A clear picture of the mechanisms of action of the anti-epileptic agent gabapentin is far from being accomplished. We have analyzed the effects of gabapentin on ligand- and voltage-gated currents in isolated adult rat cortical neurons. Gabapentin failed to modify glutamate currents and produced a slight reduction of GABA responses. Negligible inhibition of sodium, but consistent inhibition of high-voltage-activated calcium conductance was promoted by gabapentin. In addition, gabapentin reduced calcium current sensitivity to dihydropyridine agonist and antagonists. Interestingly, gabapentin also decreased a not-inactivating, cadmium-sensitive, potassium current. These unconventional effects might underlie its efficacy in a variety of diseases which involve periodic discharge patterns as neuropathic pain or essential tremor.

Original languageEnglish
Pages (from-to)239-248
Number of pages10
JournalEpilepsy Research
Volume43
Issue number3
DOIs
Publication statusPublished - Mar 1 2001

Keywords

  • Antiepileptic drugs
  • Calcium currents
  • Calcium-dependent potassium currents

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

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