The effects of garlic powder tablets in subclinical carotid atherosclerosis

Igor A. Sobenin, Nikolay V. Korneev, Igor V. Romanov, Irina V. Shutikhina, Galina I. Kuntsevich, Elena B. Romanenko, Veronica A. Myasoedova, Victor V. Revin, Alexander N. Orekhov

Research output: Contribution to journalArticle

Abstract

This study was designed to estimate the effect of time-released garlic powder tablets Allicor on the progression of carotid atherosclerosis in 211 asymptomatic men aged 40-74 in double-blinded placebo-controlled clinical trial. The primary outcome was the rate of atherosclerosis progression, measured by B-mode ultrasonography as the increase in carotid intima-media thickness (cIMT). In Allicor-treated group the decrease of cIMT by 0.028±0.008 mm was observed, whereas in placebo group there was a moderate progression at the rate of 0.014±0.009 mm per 12 months (P=0.002 for the difference). Serum atherogenicity (the ability of serum to induce cholesterol accumulation in cultured cells) was lowered in Allicor-treated patients by 45% from the baseline level, on an average. In the placebo group, serum atherogenic potential did not change significantly. These results demonstrate that long-term treatment with Allicor provides a direct antiatherosclerotic effect on subclinical carotid atherosclerosis, and this effect may be due to serum atherogenicity inhibition.

Original languageEnglish
Pages (from-to)629-638
Number of pages10
JournalExperimental and Clinical Cardiology
Volume20
Issue number1
Publication statusPublished - 2014

Keywords

  • Allicor
  • Atherosclerosis
  • Garlic
  • Intima-media thickness
  • Regression

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

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  • Cite this

    Sobenin, I. A., Korneev, N. V., Romanov, I. V., Shutikhina, I. V., Kuntsevich, G. I., Romanenko, E. B., Myasoedova, V. A., Revin, V. V., & Orekhov, A. N. (2014). The effects of garlic powder tablets in subclinical carotid atherosclerosis. Experimental and Clinical Cardiology, 20(1), 629-638.