The effects of gender on electrical therapies for the heart: Physiology, epidemiology, and access to therapies

Giuseppe Boriani, Stefano Lorenzetti, Elisabetta Cerbai, Giuseppe Oreto, Gabriele Bronzetti, Vincenzo Livio Malavasi, Alessandro Biffi, Luigi Padeletti, Gianluca Botto, Igor Diemberger

Research output: Contribution to journalReview article

Abstract

The difference between men and women is clear even just by looking at an electrocardiogram: females present higher resting heart rate, a shorter QRS complex length and greater corrected QT interval. The development of these differences from pubertal age onward suggests that sexual hormones play a key role, although their effect is far from being completely understood. Different incidences between sexes have been reported for many arrhythmias, both ventricular and supraventricular, and also for sudden cardiac death. Moreover, arrhythmias are an important issue during pregnancy, both for diagnosis and treatment. Interestingly, cardiovascular structural and electrophysiological remodelling promoted by exercise training enhances this 'gender effect'. Despite all these relevant issues, we lack gender specific recommendations in the current guidelines for electrical therapies for heart rhythm disorders and heart failure. Even more, we continue to see that fewer women are included in clinical trials and are less referred than men for these treatments.

Original languageEnglish
Pages (from-to)1418-1426
Number of pages9
JournalEuropace
Volume19
Issue number9
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • Ablation
  • Arrhythmia
  • Defibrillator
  • Exercise
  • Gender
  • Pregnancy
  • Review
  • Sex

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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  • Cite this

    Boriani, G., Lorenzetti, S., Cerbai, E., Oreto, G., Bronzetti, G., Malavasi, V. L., Biffi, A., Padeletti, L., Botto, G., & Diemberger, I. (2017). The effects of gender on electrical therapies for the heart: Physiology, epidemiology, and access to therapies. Europace, 19(9), 1418-1426. https://doi.org/10.1093/europace/eux068