The effects of igm rheumatoid factor on eam and eag rosette formation with fc receptor‐bearing lymphoid cells

Rebecca P. Emmons, John S. Davis Iv, Lorenzo Moretta

Research output: Contribution to journalArticlepeer-review


IgM rheumatoid factors (IgM‐RF) and IgM from normal donors (IgM‐C) were tested for their effects on rosette formation of Fc receptor (FcR)‐bearing lymphoid cells with IgM‐ or IgG‐coated bovine red blood cells (EAM or G). All cell populations tested bearing FcR for IgG (FcRG) showed reduced numbers of EAG rosettes formed in the presence of IgM‐RF; IgM‐C had no effect on EAG rosette formation with FcRG‐bearing cells. T cells or L cells bearing FcRM showed reduced numbers of EAM rosettes in the presence of any IgM preparation. In addition, IgM‐RF facilitated EAG‐ro‐sette formation with TM cells. These studies confirm that native IgM can bind to FcRM, blocking EAM rosettes, and that IgM‐RF can modulate the binding of an IgG‐containing immune complex to FcR‐bearing cells.

Original languageEnglish
Pages (from-to)1098-1103
Number of pages6
JournalArthritis Care and Research
Issue number9
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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