EFFETTI DELLA KETANSERINA SULLO STATO PSICHICO DI PAZIENTI ANZIANI IPERTESI

Translated title of the contribution: The effects of ketanserin on the mood of elderly hypertensive patients

N. Martucci, P. Caratozzolo, G. Nappi, G. Micieli, M. Rubegni, D. Provvedi, U. Senin, A. Longo, C. Benvenuti, P. Rodegher

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The effects of ketanserin and captopril on mood disturbances were compared in a double blind study of elderly hypertensive patients. Ketanserin (Serepress-Formenti) is a pure antagonist of central and peripheral 5HT2 receptors and inhibits peripheral vasoconstriction and lowers blood pressure. Since the 5HT2 receptors are also involved in depression (their numbers and activity are increased), we wished to see if ketanserin might also affect mood and therefore help to improve the quality of life. We enrolled 90 patients (45 to be treated with ketanserin and 45 with captopril), mean age 69.9 years, 27 M and 63 F, with slight-moderate hypertension and with dysthymia or adaptation disturbances and depressed mood, according to the DSM-III-R. After two weeks of wash-out with placebo, the patients were randomly assigned to treatment with 40 mg ketanserin, bid, or 25 mg captopril, bid, for a period of 8 weeks. Analysis by the Hamilton Rating Scale for Depression and Anxiety showed statistically significant decreases in the mean scores on both scales, for both drugs (p

Original languageItalian
Title of host publicationGeriatria
Pages43-50
Number of pages8
Volume6
Edition1
Publication statusPublished - 1994

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Ketanserin
Captopril
Depression
Vasoconstriction
Double-Blind Method
Diagnostic and Statistical Manual of Mental Disorders
Anxiety
Placebos
Quality of Life
Blood Pressure
Hypertension
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Martucci, N., Caratozzolo, P., Nappi, G., Micieli, G., Rubegni, M., Provvedi, D., ... Rodegher, P. (1994). EFFETTI DELLA KETANSERINA SULLO STATO PSICHICO DI PAZIENTI ANZIANI IPERTESI. In Geriatria (1 ed., Vol. 6, pp. 43-50)

EFFETTI DELLA KETANSERINA SULLO STATO PSICHICO DI PAZIENTI ANZIANI IPERTESI. / Martucci, N.; Caratozzolo, P.; Nappi, G.; Micieli, G.; Rubegni, M.; Provvedi, D.; Senin, U.; Longo, A.; Benvenuti, C.; Rodegher, P.

Geriatria. Vol. 6 1. ed. 1994. p. 43-50.

Research output: Chapter in Book/Report/Conference proceedingChapter

Martucci, N, Caratozzolo, P, Nappi, G, Micieli, G, Rubegni, M, Provvedi, D, Senin, U, Longo, A, Benvenuti, C & Rodegher, P 1994, EFFETTI DELLA KETANSERINA SULLO STATO PSICHICO DI PAZIENTI ANZIANI IPERTESI. in Geriatria. 1 edn, vol. 6, pp. 43-50.
Martucci N, Caratozzolo P, Nappi G, Micieli G, Rubegni M, Provvedi D et al. EFFETTI DELLA KETANSERINA SULLO STATO PSICHICO DI PAZIENTI ANZIANI IPERTESI. In Geriatria. 1 ed. Vol. 6. 1994. p. 43-50
Martucci, N. ; Caratozzolo, P. ; Nappi, G. ; Micieli, G. ; Rubegni, M. ; Provvedi, D. ; Senin, U. ; Longo, A. ; Benvenuti, C. ; Rodegher, P. / EFFETTI DELLA KETANSERINA SULLO STATO PSICHICO DI PAZIENTI ANZIANI IPERTESI. Geriatria. Vol. 6 1. ed. 1994. pp. 43-50
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