Abstract
The clinical observation of a beneficial action of L-acetylcarnitine (L-Ac) on functional recovery in patients who have suffered a stroke prompted us to investigate such effects in detail and to quantify the efficacy of the drug by means of a number of tests. Verbal and numerical memory, non-verbal performance, reaction times (simple and multiple-choice) and computerized EEG in 12 patients undergoing rehabilitation treatment for stroke were evaluated. Randomized 4-week courses of therapy with L-Ac 1500 mg daily and placebo were given according to a double-blind cross-over design. L-Ac proved to be significantly more active than placebo in the memory and non-verbal performance tests. In addition, simple reaction times proved to be significantly reduced as compared to controls.
| Original language | English |
|---|---|
| Pages (from-to) | 47-56 |
| Number of pages | 10 |
| Journal | Clinical Trials Journal |
| Volume | 25 |
| Issue number | SUPPL. 1 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Pharmacology (medical)
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The effects of L-acetylcarnitine on reaction times in patients with cerebrovascular insufficiency. A double blind cross-over study. / Arrigo, A.; Clano, E.; Casale, R.; Buonocore, M.
In: Clinical Trials Journal, Vol. 25, No. SUPPL. 1, 1988, p. 47-56.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of L-acetylcarnitine on reaction times in patients with cerebrovascular insufficiency. A double blind cross-over study
AU - Arrigo, A.
AU - Clano, E.
AU - Casale, R.
AU - Buonocore, M.
PY - 1988
Y1 - 1988
N2 - The clinical observation of a beneficial action of L-acetylcarnitine (L-Ac) on functional recovery in patients who have suffered a stroke prompted us to investigate such effects in detail and to quantify the efficacy of the drug by means of a number of tests. Verbal and numerical memory, non-verbal performance, reaction times (simple and multiple-choice) and computerized EEG in 12 patients undergoing rehabilitation treatment for stroke were evaluated. Randomized 4-week courses of therapy with L-Ac 1500 mg daily and placebo were given according to a double-blind cross-over design. L-Ac proved to be significantly more active than placebo in the memory and non-verbal performance tests. In addition, simple reaction times proved to be significantly reduced as compared to controls.
AB - The clinical observation of a beneficial action of L-acetylcarnitine (L-Ac) on functional recovery in patients who have suffered a stroke prompted us to investigate such effects in detail and to quantify the efficacy of the drug by means of a number of tests. Verbal and numerical memory, non-verbal performance, reaction times (simple and multiple-choice) and computerized EEG in 12 patients undergoing rehabilitation treatment for stroke were evaluated. Randomized 4-week courses of therapy with L-Ac 1500 mg daily and placebo were given according to a double-blind cross-over design. L-Ac proved to be significantly more active than placebo in the memory and non-verbal performance tests. In addition, simple reaction times proved to be significantly reduced as compared to controls.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024271371&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0024271371
VL - 25
SP - 47
EP - 56
JO - Clinical Trials Journal
JF - Clinical Trials Journal
SN - 0009-9325
IS - SUPPL. 1
ER -