The effects of L-acetylcarnitine on reaction times in patients with cerebrovascular insufficiency. A double blind cross-over study

A. Arrigo, E. Clano, R. Casale, M. Buonocore

Research output: Contribution to journalArticle

Abstract

The clinical observation of a beneficial action of L-acetylcarnitine (L-Ac) on functional recovery in patients who have suffered a stroke prompted us to investigate such effects in detail and to quantify the efficacy of the drug by means of a number of tests. Verbal and numerical memory, non-verbal performance, reaction times (simple and multiple-choice) and computerized EEG in 12 patients undergoing rehabilitation treatment for stroke were evaluated. Randomized 4-week courses of therapy with L-Ac 1500 mg daily and placebo were given according to a double-blind cross-over design. L-Ac proved to be significantly more active than placebo in the memory and non-verbal performance tests. In addition, simple reaction times proved to be significantly reduced as compared to controls.

Original languageEnglish
Pages (from-to)47-56
Number of pages10
JournalClinical Trials Journal
Volume25
Issue numberSUPPL. 1
Publication statusPublished - 1988

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Acetylcarnitine
Cerebrovascular Disorders
Cross-Over Studies
Reaction Time
Placebos
Electroencephalography
Stroke
Observation
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

The effects of L-acetylcarnitine on reaction times in patients with cerebrovascular insufficiency. A double blind cross-over study. / Arrigo, A.; Clano, E.; Casale, R.; Buonocore, M.

In: Clinical Trials Journal, Vol. 25, No. SUPPL. 1, 1988, p. 47-56.

Research output: Contribution to journalArticle

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