The effects of levodopa and deep brain stimulation on subthalamic local field low-frequency oscillations in parkinson's disease

Gaia Giannicola, Manuela Rosa, Sara Marceglia, Emma Scelzo, Lorenzo Rossi, Domenico Servello, Claudia Menghetti, Claudio Pacchetti, Roberta Zangaglia, Marco Locatelli, Elena Caputo, Filippo Cogiamanian, Gianluca Ardolino, Sergio Barbieri, Alberto Priori

Research output: Contribution to journalArticle

Abstract

New adaptive systems for deep brain stimulation (DBS) could in the near future optimize stimulation settings online so as to achieve better control over the clinical fluctuations in Parkinson's disease (PD). Local field potentials (LFPs) recorded from the subthalamic nucleus (STN) in PD patients show that levodopa and DBS modulate STN oscillations. Because previous research has shown that levodopa and DBS variably influence beta LFP activity (8-20 Hz), we designed this study to find out how they affect low-frequency (LF) oscillations (2-7 Hz). STN LFPs were recorded in 19 patients with PD during DBS, after levodopa medication, and during DBS and levodopa intake combined. We investigated the relationship between LF modulations, DBS duration and levodopa intake. We also studied whether LF power depended on disease severity, the patient's clinical condition and whether LF modulations were related to electrode impedances. LF power increased during DBS, after levodopa intake and under both experimental conditions combined. The LF power increase correlated with the levodopa-induced clinical improvement and the higher the electrode impedance, the greater was the LF power change. These data suggest that the LF band could be useful as a control neurosignal for developing novel adaptive DBS systems for patients with PD.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalNeuroSignals
Volume21
Issue number1-2
DOIs
Publication statusPublished - Feb 2013

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Deep Brain Stimulation
Levodopa
Parkinson Disease
Subthalamic Nucleus
Electric Impedance
Electrodes
Research

Keywords

  • Deep brain stimulation
  • Levodopa
  • Local field potentials
  • Low frequency
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neurology
  • Developmental Neuroscience

Cite this

The effects of levodopa and deep brain stimulation on subthalamic local field low-frequency oscillations in parkinson's disease. / Giannicola, Gaia; Rosa, Manuela; Marceglia, Sara; Scelzo, Emma; Rossi, Lorenzo; Servello, Domenico; Menghetti, Claudia; Pacchetti, Claudio; Zangaglia, Roberta; Locatelli, Marco; Caputo, Elena; Cogiamanian, Filippo; Ardolino, Gianluca; Barbieri, Sergio; Priori, Alberto.

In: NeuroSignals, Vol. 21, No. 1-2, 02.2013, p. 89-98.

Research output: Contribution to journalArticle

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