The effects of levodopa and ongoing deep brain stimulation on subthalamic beta oscillations in Parkinson's disease

Gaia Giannicola, Sara Marceglia, Lorenzo Rossi, Simona Mrakic-Sposta, Paolo Rampini, Filippo Tamma, Filippo Cogiamanian, SERGIO Barbieri, A. Priori

Research output: Contribution to journalArticle

Abstract

Local field potentials (LFPs) recorded through electrodes implanted in the subthalamic nucleus (STN) for deep brain stimulation (DBS) in patients with Parkinson's disease (PD) show that oscillations in the beta frequency range (8-20. Hz) decrease after levodopa intake. Whether and how DBS influences the beta oscillations and whether levodopa- and DBS-induced changes interact remains unclear. We examined the combined effect of levodopa and DBS on subthalamic beta LFP oscillations, recorded in nine patients with PD under four experimental conditions: without levodopa with DBS turned off; without levodopa with DBS turned on; with levodopa with DBS turned on; and with levodopa with DBS turned off. The analysis of STN-LFP oscillations showed that whereas levodopa abolished beta STN oscillations in all the patients (p= 0.026), DBS significantly decreased the beta oscillation only in five of the nine patients studied (p= 0.043). Another difference was that whereas levodopa completely suppressed beta oscillations, DBS merely decreased them. When we combined levodopa and DBS, the levodopa-induced beta disruption prevailed and combining levodopa and DBS induced no significant additive effect (p=0.500). Our observations suggest that levodopa and DBS both modulate LFP beta oscillations.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalExperimental Neurology
Volume226
Issue number1
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Beta rhythm
  • Deep brain stimulation
  • Levodopa
  • Local field potentials
  • Parkinson's disease
  • Subthalamic oscillations

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Medicine(all)

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