The effects of levosulpiride on gastric and gall-bladder emptying in functional dyspepsia

V. Arienti, G. R. Corazza, M. Sorge, L. Boriani, F. Ugenti, F. Biagi, G. Maconi, S. Sottili, D. H. Van Thiel, G. Gasbarrini

Research output: Contribution to journalArticle

Abstract

Background: 50% of patients with functional dyspepsia have delayed gastric emptying. Levosulpiride is an orthopramide drug that stimulates gastrointestinal motility. Aim of our study was to evaluate the effect of levosulpiride on symptoms and gastric and gall-bladder emptying, in dyspeptic patients. Methods: Thirty adult patients, treated for 20 days with levosulpiride (75 mg/day) or placebo, were evaluated in a randomized double-blind study. Symptoms were assessed by a cumulative index and overall intensity (visual analogue line). Gastric and gall-bladder emptying were evaluated by epigastric impedance (liquid meal) and real-time ultrasonography (mixed meal). Results: Levosulpiride, with respect to placebo, accelerated the mean gastric half-emptying time of liquids (P <0.05), gastric emptying (P <0.001 at 180 min; P <0.05 at 240 min), and gall-bladder emptying (P <0.05 at 60 and 120 min) emptying after a solid-liquid mixed meal. Both the mean Cumulative index (P <0.05) and the overall intensity (P <0.025) of dyspeptic symptoms were reduced significantly by levosulpiride. Conclusions: Our results showed that levosulpiride can be usefully employed in patients affected by functional dyspepsia.

Original languageEnglish
Pages (from-to)631-638
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Volume8
Issue number6
Publication statusPublished - 1994

Fingerprint

Gallbladder Emptying
Dyspepsia
Stomach
Gastric Emptying
Meals
Placebos
Gastrointestinal Motility
Electric Impedance
Double-Blind Method
levosulpiride
Ultrasonography
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The effects of levosulpiride on gastric and gall-bladder emptying in functional dyspepsia. / Arienti, V.; Corazza, G. R.; Sorge, M.; Boriani, L.; Ugenti, F.; Biagi, F.; Maconi, G.; Sottili, S.; Van Thiel, D. H.; Gasbarrini, G.

In: Alimentary Pharmacology and Therapeutics, Vol. 8, No. 6, 1994, p. 631-638.

Research output: Contribution to journalArticle

Arienti, V, Corazza, GR, Sorge, M, Boriani, L, Ugenti, F, Biagi, F, Maconi, G, Sottili, S, Van Thiel, DH & Gasbarrini, G 1994, 'The effects of levosulpiride on gastric and gall-bladder emptying in functional dyspepsia', Alimentary Pharmacology and Therapeutics, vol. 8, no. 6, pp. 631-638.
Arienti, V. ; Corazza, G. R. ; Sorge, M. ; Boriani, L. ; Ugenti, F. ; Biagi, F. ; Maconi, G. ; Sottili, S. ; Van Thiel, D. H. ; Gasbarrini, G. / The effects of levosulpiride on gastric and gall-bladder emptying in functional dyspepsia. In: Alimentary Pharmacology and Therapeutics. 1994 ; Vol. 8, No. 6. pp. 631-638.
@article{ca40e3d5257f4f5ca6db0b2d3311c8e9,
title = "The effects of levosulpiride on gastric and gall-bladder emptying in functional dyspepsia",
abstract = "Background: 50{\%} of patients with functional dyspepsia have delayed gastric emptying. Levosulpiride is an orthopramide drug that stimulates gastrointestinal motility. Aim of our study was to evaluate the effect of levosulpiride on symptoms and gastric and gall-bladder emptying, in dyspeptic patients. Methods: Thirty adult patients, treated for 20 days with levosulpiride (75 mg/day) or placebo, were evaluated in a randomized double-blind study. Symptoms were assessed by a cumulative index and overall intensity (visual analogue line). Gastric and gall-bladder emptying were evaluated by epigastric impedance (liquid meal) and real-time ultrasonography (mixed meal). Results: Levosulpiride, with respect to placebo, accelerated the mean gastric half-emptying time of liquids (P <0.05), gastric emptying (P <0.001 at 180 min; P <0.05 at 240 min), and gall-bladder emptying (P <0.05 at 60 and 120 min) emptying after a solid-liquid mixed meal. Both the mean Cumulative index (P <0.05) and the overall intensity (P <0.025) of dyspeptic symptoms were reduced significantly by levosulpiride. Conclusions: Our results showed that levosulpiride can be usefully employed in patients affected by functional dyspepsia.",
author = "V. Arienti and Corazza, {G. R.} and M. Sorge and L. Boriani and F. Ugenti and F. Biagi and G. Maconi and S. Sottili and {Van Thiel}, {D. H.} and G. Gasbarrini",
year = "1994",
language = "English",
volume = "8",
pages = "631--638",
journal = "Alimentary Pharmacology and Therapeutics",
issn = "0269-2813",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "6",

}

TY - JOUR

T1 - The effects of levosulpiride on gastric and gall-bladder emptying in functional dyspepsia

AU - Arienti, V.

AU - Corazza, G. R.

AU - Sorge, M.

AU - Boriani, L.

AU - Ugenti, F.

AU - Biagi, F.

AU - Maconi, G.

AU - Sottili, S.

AU - Van Thiel, D. H.

AU - Gasbarrini, G.

PY - 1994

Y1 - 1994

N2 - Background: 50% of patients with functional dyspepsia have delayed gastric emptying. Levosulpiride is an orthopramide drug that stimulates gastrointestinal motility. Aim of our study was to evaluate the effect of levosulpiride on symptoms and gastric and gall-bladder emptying, in dyspeptic patients. Methods: Thirty adult patients, treated for 20 days with levosulpiride (75 mg/day) or placebo, were evaluated in a randomized double-blind study. Symptoms were assessed by a cumulative index and overall intensity (visual analogue line). Gastric and gall-bladder emptying were evaluated by epigastric impedance (liquid meal) and real-time ultrasonography (mixed meal). Results: Levosulpiride, with respect to placebo, accelerated the mean gastric half-emptying time of liquids (P <0.05), gastric emptying (P <0.001 at 180 min; P <0.05 at 240 min), and gall-bladder emptying (P <0.05 at 60 and 120 min) emptying after a solid-liquid mixed meal. Both the mean Cumulative index (P <0.05) and the overall intensity (P <0.025) of dyspeptic symptoms were reduced significantly by levosulpiride. Conclusions: Our results showed that levosulpiride can be usefully employed in patients affected by functional dyspepsia.

AB - Background: 50% of patients with functional dyspepsia have delayed gastric emptying. Levosulpiride is an orthopramide drug that stimulates gastrointestinal motility. Aim of our study was to evaluate the effect of levosulpiride on symptoms and gastric and gall-bladder emptying, in dyspeptic patients. Methods: Thirty adult patients, treated for 20 days with levosulpiride (75 mg/day) or placebo, were evaluated in a randomized double-blind study. Symptoms were assessed by a cumulative index and overall intensity (visual analogue line). Gastric and gall-bladder emptying were evaluated by epigastric impedance (liquid meal) and real-time ultrasonography (mixed meal). Results: Levosulpiride, with respect to placebo, accelerated the mean gastric half-emptying time of liquids (P <0.05), gastric emptying (P <0.001 at 180 min; P <0.05 at 240 min), and gall-bladder emptying (P <0.05 at 60 and 120 min) emptying after a solid-liquid mixed meal. Both the mean Cumulative index (P <0.05) and the overall intensity (P <0.025) of dyspeptic symptoms were reduced significantly by levosulpiride. Conclusions: Our results showed that levosulpiride can be usefully employed in patients affected by functional dyspepsia.

UR - http://www.scopus.com/inward/record.url?scp=0028000312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028000312&partnerID=8YFLogxK

M3 - Article

C2 - 7734028

AN - SCOPUS:0028000312

VL - 8

SP - 631

EP - 638

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

SN - 0269-2813

IS - 6

ER -