Abstract
Background: 50% of patients with functional dyspepsia have delayed gastric emptying. Levosulpiride is an orthopramide drug that stimulates gastrointestinal motility. Aim of our study was to evaluate the effect of levosulpiride on symptoms and gastric and gall-bladder emptying, in dyspeptic patients. Methods: Thirty adult patients, treated for 20 days with levosulpiride (75 mg/day) or placebo, were evaluated in a randomized double-blind study. Symptoms were assessed by a cumulative index and overall intensity (visual analogue line). Gastric and gall-bladder emptying were evaluated by epigastric impedance (liquid meal) and real-time ultrasonography (mixed meal). Results: Levosulpiride, with respect to placebo, accelerated the mean gastric half-emptying time of liquids (P <0.05), gastric emptying (P <0.001 at 180 min; P <0.05 at 240 min), and gall-bladder emptying (P <0.05 at 60 and 120 min) emptying after a solid-liquid mixed meal. Both the mean Cumulative index (P <0.05) and the overall intensity (P <0.025) of dyspeptic symptoms were reduced significantly by levosulpiride. Conclusions: Our results showed that levosulpiride can be usefully employed in patients affected by functional dyspepsia.
| Original language | English |
|---|---|
| Pages (from-to) | 631-638 |
| Number of pages | 8 |
| Journal | Alimentary Pharmacology and Therapeutics |
| Volume | 8 |
| Issue number | 6 |
| Publication status | Published - 1994 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
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The effects of levosulpiride on gastric and gall-bladder emptying in functional dyspepsia. / Arienti, V.; Corazza, G. R.; Sorge, M.; Boriani, L.; Ugenti, F.; Biagi, F.; Maconi, G.; Sottili, S.; Van Thiel, D. H.; Gasbarrini, G.
In: Alimentary Pharmacology and Therapeutics, Vol. 8, No. 6, 1994, p. 631-638.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of levosulpiride on gastric and gall-bladder emptying in functional dyspepsia
AU - Arienti, V.
AU - Corazza, G. R.
AU - Sorge, M.
AU - Boriani, L.
AU - Ugenti, F.
AU - Biagi, F.
AU - Maconi, G.
AU - Sottili, S.
AU - Van Thiel, D. H.
AU - Gasbarrini, G.
PY - 1994
Y1 - 1994
N2 - Background: 50% of patients with functional dyspepsia have delayed gastric emptying. Levosulpiride is an orthopramide drug that stimulates gastrointestinal motility. Aim of our study was to evaluate the effect of levosulpiride on symptoms and gastric and gall-bladder emptying, in dyspeptic patients. Methods: Thirty adult patients, treated for 20 days with levosulpiride (75 mg/day) or placebo, were evaluated in a randomized double-blind study. Symptoms were assessed by a cumulative index and overall intensity (visual analogue line). Gastric and gall-bladder emptying were evaluated by epigastric impedance (liquid meal) and real-time ultrasonography (mixed meal). Results: Levosulpiride, with respect to placebo, accelerated the mean gastric half-emptying time of liquids (P <0.05), gastric emptying (P <0.001 at 180 min; P <0.05 at 240 min), and gall-bladder emptying (P <0.05 at 60 and 120 min) emptying after a solid-liquid mixed meal. Both the mean Cumulative index (P <0.05) and the overall intensity (P <0.025) of dyspeptic symptoms were reduced significantly by levosulpiride. Conclusions: Our results showed that levosulpiride can be usefully employed in patients affected by functional dyspepsia.
AB - Background: 50% of patients with functional dyspepsia have delayed gastric emptying. Levosulpiride is an orthopramide drug that stimulates gastrointestinal motility. Aim of our study was to evaluate the effect of levosulpiride on symptoms and gastric and gall-bladder emptying, in dyspeptic patients. Methods: Thirty adult patients, treated for 20 days with levosulpiride (75 mg/day) or placebo, were evaluated in a randomized double-blind study. Symptoms were assessed by a cumulative index and overall intensity (visual analogue line). Gastric and gall-bladder emptying were evaluated by epigastric impedance (liquid meal) and real-time ultrasonography (mixed meal). Results: Levosulpiride, with respect to placebo, accelerated the mean gastric half-emptying time of liquids (P <0.05), gastric emptying (P <0.001 at 180 min; P <0.05 at 240 min), and gall-bladder emptying (P <0.05 at 60 and 120 min) emptying after a solid-liquid mixed meal. Both the mean Cumulative index (P <0.05) and the overall intensity (P <0.025) of dyspeptic symptoms were reduced significantly by levosulpiride. Conclusions: Our results showed that levosulpiride can be usefully employed in patients affected by functional dyspepsia.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028000312&partnerID=8YFLogxK
M3 - Article
C2 - 7734028
AN - SCOPUS:0028000312
VL - 8
SP - 631
EP - 638
JO - Alimentary Pharmacology and Therapeutics
JF - Alimentary Pharmacology and Therapeutics
SN - 0269-2813
IS - 6
ER -