The effects of locus coeruleus and norepinephrine in methamphetamine toxicity

Michela Ferrucci, Filippo S. Giorgi, Alessia Bartalucci, Carla L. Busceti, Francesco Fornai

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focuses on the modulation exerted by central NE pathways on the behavioural and neurotoxic effects produced by the psychostimulant methamphetamine, essentially the modulation of the activity of mesencephalic dopamine (DA) neurons. In fact, although NE in itself mediates some behavioural effects induced by methamphetamine, NE modulation of DA release is pivotal for methamphetamine-induced behavioural states and neurotoxicity. These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters.

Original languageEnglish
Pages (from-to)80-94
Number of pages15
JournalCurrent Neuropharmacology
Volume11
Issue number1
Publication statusPublished - 2013

Fingerprint

Locus Coeruleus
Methamphetamine
Norepinephrine
Dopamine
Neuroanatomy
Dopaminergic Neurons
Movement Disorders
Opioid Analgesics
Neurotransmitter Agents
Sleep
Seizures
Neurons
Brain
Pharmaceutical Preparations

Keywords

  • Behaviour
  • Dopamine
  • Drugs of Abuse
  • Locus Coeruleus
  • Methamphetamine
  • Neurochemistry
  • Norepinephrine
  • Substantia Nigra

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology
  • Neurology
  • Psychiatry and Mental health

Cite this

The effects of locus coeruleus and norepinephrine in methamphetamine toxicity. / Ferrucci, Michela; Giorgi, Filippo S.; Bartalucci, Alessia; Busceti, Carla L.; Fornai, Francesco.

In: Current Neuropharmacology, Vol. 11, No. 1, 2013, p. 80-94.

Research output: Contribution to journalArticle

Ferrucci, Michela ; Giorgi, Filippo S. ; Bartalucci, Alessia ; Busceti, Carla L. ; Fornai, Francesco. / The effects of locus coeruleus and norepinephrine in methamphetamine toxicity. In: Current Neuropharmacology. 2013 ; Vol. 11, No. 1. pp. 80-94.
@article{4d1aba4532104a3bb03e2eefe661f28a,
title = "The effects of locus coeruleus and norepinephrine in methamphetamine toxicity",
abstract = "The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focuses on the modulation exerted by central NE pathways on the behavioural and neurotoxic effects produced by the psychostimulant methamphetamine, essentially the modulation of the activity of mesencephalic dopamine (DA) neurons. In fact, although NE in itself mediates some behavioural effects induced by methamphetamine, NE modulation of DA release is pivotal for methamphetamine-induced behavioural states and neurotoxicity. These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters.",
keywords = "Behaviour, Dopamine, Drugs of Abuse, Locus Coeruleus, Methamphetamine, Neurochemistry, Norepinephrine, Substantia Nigra",
author = "Michela Ferrucci and Giorgi, {Filippo S.} and Alessia Bartalucci and Busceti, {Carla L.} and Francesco Fornai",
year = "2013",
language = "English",
volume = "11",
pages = "80--94",
journal = "Current Neuropharmacology",
issn = "1570-159X",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - The effects of locus coeruleus and norepinephrine in methamphetamine toxicity

AU - Ferrucci, Michela

AU - Giorgi, Filippo S.

AU - Bartalucci, Alessia

AU - Busceti, Carla L.

AU - Fornai, Francesco

PY - 2013

Y1 - 2013

N2 - The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focuses on the modulation exerted by central NE pathways on the behavioural and neurotoxic effects produced by the psychostimulant methamphetamine, essentially the modulation of the activity of mesencephalic dopamine (DA) neurons. In fact, although NE in itself mediates some behavioural effects induced by methamphetamine, NE modulation of DA release is pivotal for methamphetamine-induced behavioural states and neurotoxicity. These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters.

AB - The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focuses on the modulation exerted by central NE pathways on the behavioural and neurotoxic effects produced by the psychostimulant methamphetamine, essentially the modulation of the activity of mesencephalic dopamine (DA) neurons. In fact, although NE in itself mediates some behavioural effects induced by methamphetamine, NE modulation of DA release is pivotal for methamphetamine-induced behavioural states and neurotoxicity. These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters.

KW - Behaviour

KW - Dopamine

KW - Drugs of Abuse

KW - Locus Coeruleus

KW - Methamphetamine

KW - Neurochemistry

KW - Norepinephrine

KW - Substantia Nigra

UR - http://www.scopus.com/inward/record.url?scp=84874912199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874912199&partnerID=8YFLogxK

M3 - Article

VL - 11

SP - 80

EP - 94

JO - Current Neuropharmacology

JF - Current Neuropharmacology

SN - 1570-159X

IS - 1

ER -