Lymphocytes obtained from the periferal blood of normal donors and patients suffering from B-chronic lymphocytic leukemia (B-CLL) were cultured. Lymphocyte cultures containing phytohemagglutinin (PHA) were exposed to low frequency pulsing electromagnetic fields (PEMFs). An increase in cell proliferation was observed when relatively "low" amplitude electromagnetic fields were used. By increasing the amplitude of the electromagnetic field, a reversal effect was obtained and inhibition of lymphocyte proliferation was observed. Lymphocyte cultures exposed to low amplitude PEMFs showed increased cell proliferation also when cultured in the presence of sub-optimum concentrations of PHA. Data are presented showing that in consequence of PEMF exposure more B-cell soluble growth factors are found in the culture medium.
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