The effects of low frequency pulsing electromagnetic fields on the response of human lymphocytes to lectins. Changes at different values of induced electrical tension

R. Cadossi, G. B. Ceccherelli, G. Emilia, G. Torelli, M. P. Ruggieri, F. Bersani, A. Cossarizza, C. Franceschi

Research output: Contribution to journalArticle

Abstract

Lymphocytes obtained from the periferal blood of normal donors and patients suffering from B-chronic lymphocytic leukemia (B-CLL) were cultured. Lymphocyte cultures containing phytohemagglutinin (PHA) were exposed to low frequency pulsing electromagnetic fields (PEMFs). An increase in cell proliferation was observed when relatively "low" amplitude electromagnetic fields were used. By increasing the amplitude of the electromagnetic field, a reversal effect was obtained and inhibition of lymphocyte proliferation was observed. Lymphocyte cultures exposed to low amplitude PEMFs showed increased cell proliferation also when cultured in the presence of sub-optimum concentrations of PHA. Data are presented showing that in consequence of PEMF exposure more B-cell soluble growth factors are found in the culture medium.

Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalBioelectrochemistry and Bioenergetics
Volume19
Issue number2
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Biochemistry

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