Abstract
Background. Posttransplant diabetes mellitus (PTDM) has gained widespread attention due to the micro and macro-vascular complications that increase the morbidity and mortality of patients receiving solid organs. The higher incidence of PTDM has been mainly attributed to the immunosuppressive therapy. Therefore, this study compares the metabolic side effects of low dose maintenance therapy of FK-506 and Cyclosporin A (CsA) in 14 patients 1 year after orthotopic liver transplant and analyzes possible factors that contribute to the development of PTDM. Methods. Two groups (n=7) differing in their immunosuppressive regimen (FK506 or CsA) were matched to eight control subjects and compared to each other. The effects of in vivo insulin action were assessed by means of the euglycemic hyperinsulinemic clamp technique. Arginine stimulation tests at normo- (5.5 mM) and hyperglycemic (15 mM) levels were performed and the acute insulin, C-peptide and glucagon response (2-5 min) to arginine were determined. Results. Insulin sensitivity (total glucose disposal) was statistically lower in patients treated with FK-506 and CsA (5.05±0.47 and 5.05±0.42 mg/kg/min) as compared to controls (6.62±0.38 mg/kg/min) (P
| Original language | English |
|---|---|
| Pages (from-to) | 1532-1541 |
| Number of pages | 10 |
| Journal | Transplantation |
| Volume | 68 |
| Issue number | 10 |
| Publication status | Published - Nov 27 1999 |
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ASJC Scopus subject areas
- Transplantation
- Immunology
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The effects of maintenance doses of FK506 versus cyclosporin a on glucose and lipid metabolism after orthotopic liver transplantation. / Fernandez, Luis A.; Lehmann, Roger; Luzi, Livio; Battezzati, Alberto; Angelico, Maria C.; Ricordi, Camillo; Tzakis, Andreas; Alejandro, Rodolfo.
In: Transplantation, Vol. 68, No. 10, 27.11.1999, p. 1532-1541.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The effects of maintenance doses of FK506 versus cyclosporin a on glucose and lipid metabolism after orthotopic liver transplantation
AU - Fernandez, Luis A.
AU - Lehmann, Roger
AU - Luzi, Livio
AU - Battezzati, Alberto
AU - Angelico, Maria C.
AU - Ricordi, Camillo
AU - Tzakis, Andreas
AU - Alejandro, Rodolfo
PY - 1999/11/27
Y1 - 1999/11/27
N2 - Background. Posttransplant diabetes mellitus (PTDM) has gained widespread attention due to the micro and macro-vascular complications that increase the morbidity and mortality of patients receiving solid organs. The higher incidence of PTDM has been mainly attributed to the immunosuppressive therapy. Therefore, this study compares the metabolic side effects of low dose maintenance therapy of FK-506 and Cyclosporin A (CsA) in 14 patients 1 year after orthotopic liver transplant and analyzes possible factors that contribute to the development of PTDM. Methods. Two groups (n=7) differing in their immunosuppressive regimen (FK506 or CsA) were matched to eight control subjects and compared to each other. The effects of in vivo insulin action were assessed by means of the euglycemic hyperinsulinemic clamp technique. Arginine stimulation tests at normo- (5.5 mM) and hyperglycemic (15 mM) levels were performed and the acute insulin, C-peptide and glucagon response (2-5 min) to arginine were determined. Results. Insulin sensitivity (total glucose disposal) was statistically lower in patients treated with FK-506 and CsA (5.05±0.47 and 5.05±0.42 mg/kg/min) as compared to controls (6.62±0.38 mg/kg/min) (P
AB - Background. Posttransplant diabetes mellitus (PTDM) has gained widespread attention due to the micro and macro-vascular complications that increase the morbidity and mortality of patients receiving solid organs. The higher incidence of PTDM has been mainly attributed to the immunosuppressive therapy. Therefore, this study compares the metabolic side effects of low dose maintenance therapy of FK-506 and Cyclosporin A (CsA) in 14 patients 1 year after orthotopic liver transplant and analyzes possible factors that contribute to the development of PTDM. Methods. Two groups (n=7) differing in their immunosuppressive regimen (FK506 or CsA) were matched to eight control subjects and compared to each other. The effects of in vivo insulin action were assessed by means of the euglycemic hyperinsulinemic clamp technique. Arginine stimulation tests at normo- (5.5 mM) and hyperglycemic (15 mM) levels were performed and the acute insulin, C-peptide and glucagon response (2-5 min) to arginine were determined. Results. Insulin sensitivity (total glucose disposal) was statistically lower in patients treated with FK-506 and CsA (5.05±0.47 and 5.05±0.42 mg/kg/min) as compared to controls (6.62±0.38 mg/kg/min) (P
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M3 - Article
VL - 68
SP - 1532
EP - 1541
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 10
ER -