The effects of maintenance doses of FK506 versus cyclosporin a on glucose and lipid metabolism after orthotopic liver transplantation

Luis A. Fernandez, Roger Lehmann, Livio Luzi, Alberto Battezzati, Maria C. Angelico, Camillo Ricordi, Andreas Tzakis, Rodolfo Alejandro

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Background. Posttransplant diabetes mellitus (PTDM) has gained widespread attention due to the micro and macro-vascular complications that increase the morbidity and mortality of patients receiving solid organs. The higher incidence of PTDM has been mainly attributed to the immunosuppressive therapy. Therefore, this study compares the metabolic side effects of low dose maintenance therapy of FK-506 and Cyclosporin A (CsA) in 14 patients 1 year after orthotopic liver transplant and analyzes possible factors that contribute to the development of PTDM. Methods. Two groups (n=7) differing in their immunosuppressive regimen (FK506 or CsA) were matched to eight control subjects and compared to each other. The effects of in vivo insulin action were assessed by means of the euglycemic hyperinsulinemic clamp technique. Arginine stimulation tests at normo- (5.5 mM) and hyperglycemic (15 mM) levels were performed and the acute insulin, C-peptide and glucagon response (2-5 min) to arginine were determined. Results. Insulin sensitivity (total glucose disposal) was statistically lower in patients treated with FK-506 and CsA (5.05±0.47 and 5.05±0.42 mg/kg/min) as compared to controls (6.62±0.38 mg/kg/min) (P

Original languageEnglish
Pages (from-to)1532-1541
Number of pages10
JournalTransplantation
Volume68
Issue number10
Publication statusPublished - Nov 27 1999

Fingerprint

Tacrolimus
Lipid Metabolism
Liver Transplantation
Cyclosporine
Diabetes Mellitus
Immunosuppressive Agents
Glucose
Arginine
Insulin
Glucose Clamp Technique
C-Peptide
Glucagon
Statistical Factor Analysis
Blood Vessels
Insulin Resistance
Morbidity
Transplants
Mortality
Liver
Incidence

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Fernandez, L. A., Lehmann, R., Luzi, L., Battezzati, A., Angelico, M. C., Ricordi, C., ... Alejandro, R. (1999). The effects of maintenance doses of FK506 versus cyclosporin a on glucose and lipid metabolism after orthotopic liver transplantation. Transplantation, 68(10), 1532-1541.

The effects of maintenance doses of FK506 versus cyclosporin a on glucose and lipid metabolism after orthotopic liver transplantation. / Fernandez, Luis A.; Lehmann, Roger; Luzi, Livio; Battezzati, Alberto; Angelico, Maria C.; Ricordi, Camillo; Tzakis, Andreas; Alejandro, Rodolfo.

In: Transplantation, Vol. 68, No. 10, 27.11.1999, p. 1532-1541.

Research output: Contribution to journalArticle

Fernandez, LA, Lehmann, R, Luzi, L, Battezzati, A, Angelico, MC, Ricordi, C, Tzakis, A & Alejandro, R 1999, 'The effects of maintenance doses of FK506 versus cyclosporin a on glucose and lipid metabolism after orthotopic liver transplantation', Transplantation, vol. 68, no. 10, pp. 1532-1541.
Fernandez, Luis A. ; Lehmann, Roger ; Luzi, Livio ; Battezzati, Alberto ; Angelico, Maria C. ; Ricordi, Camillo ; Tzakis, Andreas ; Alejandro, Rodolfo. / The effects of maintenance doses of FK506 versus cyclosporin a on glucose and lipid metabolism after orthotopic liver transplantation. In: Transplantation. 1999 ; Vol. 68, No. 10. pp. 1532-1541.
@article{06a66b699296452290eefc67bc0a5c87,
title = "The effects of maintenance doses of FK506 versus cyclosporin a on glucose and lipid metabolism after orthotopic liver transplantation",
abstract = "Background. Posttransplant diabetes mellitus (PTDM) has gained widespread attention due to the micro and macro-vascular complications that increase the morbidity and mortality of patients receiving solid organs. The higher incidence of PTDM has been mainly attributed to the immunosuppressive therapy. Therefore, this study compares the metabolic side effects of low dose maintenance therapy of FK-506 and Cyclosporin A (CsA) in 14 patients 1 year after orthotopic liver transplant and analyzes possible factors that contribute to the development of PTDM. Methods. Two groups (n=7) differing in their immunosuppressive regimen (FK506 or CsA) were matched to eight control subjects and compared to each other. The effects of in vivo insulin action were assessed by means of the euglycemic hyperinsulinemic clamp technique. Arginine stimulation tests at normo- (5.5 mM) and hyperglycemic (15 mM) levels were performed and the acute insulin, C-peptide and glucagon response (2-5 min) to arginine were determined. Results. Insulin sensitivity (total glucose disposal) was statistically lower in patients treated with FK-506 and CsA (5.05±0.47 and 5.05±0.42 mg/kg/min) as compared to controls (6.62±0.38 mg/kg/min) (P",
author = "Fernandez, {Luis A.} and Roger Lehmann and Livio Luzi and Alberto Battezzati and Angelico, {Maria C.} and Camillo Ricordi and Andreas Tzakis and Rodolfo Alejandro",
year = "1999",
month = "11",
day = "27",
language = "English",
volume = "68",
pages = "1532--1541",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - The effects of maintenance doses of FK506 versus cyclosporin a on glucose and lipid metabolism after orthotopic liver transplantation

AU - Fernandez, Luis A.

AU - Lehmann, Roger

AU - Luzi, Livio

AU - Battezzati, Alberto

AU - Angelico, Maria C.

AU - Ricordi, Camillo

AU - Tzakis, Andreas

AU - Alejandro, Rodolfo

PY - 1999/11/27

Y1 - 1999/11/27

N2 - Background. Posttransplant diabetes mellitus (PTDM) has gained widespread attention due to the micro and macro-vascular complications that increase the morbidity and mortality of patients receiving solid organs. The higher incidence of PTDM has been mainly attributed to the immunosuppressive therapy. Therefore, this study compares the metabolic side effects of low dose maintenance therapy of FK-506 and Cyclosporin A (CsA) in 14 patients 1 year after orthotopic liver transplant and analyzes possible factors that contribute to the development of PTDM. Methods. Two groups (n=7) differing in their immunosuppressive regimen (FK506 or CsA) were matched to eight control subjects and compared to each other. The effects of in vivo insulin action were assessed by means of the euglycemic hyperinsulinemic clamp technique. Arginine stimulation tests at normo- (5.5 mM) and hyperglycemic (15 mM) levels were performed and the acute insulin, C-peptide and glucagon response (2-5 min) to arginine were determined. Results. Insulin sensitivity (total glucose disposal) was statistically lower in patients treated with FK-506 and CsA (5.05±0.47 and 5.05±0.42 mg/kg/min) as compared to controls (6.62±0.38 mg/kg/min) (P

AB - Background. Posttransplant diabetes mellitus (PTDM) has gained widespread attention due to the micro and macro-vascular complications that increase the morbidity and mortality of patients receiving solid organs. The higher incidence of PTDM has been mainly attributed to the immunosuppressive therapy. Therefore, this study compares the metabolic side effects of low dose maintenance therapy of FK-506 and Cyclosporin A (CsA) in 14 patients 1 year after orthotopic liver transplant and analyzes possible factors that contribute to the development of PTDM. Methods. Two groups (n=7) differing in their immunosuppressive regimen (FK506 or CsA) were matched to eight control subjects and compared to each other. The effects of in vivo insulin action were assessed by means of the euglycemic hyperinsulinemic clamp technique. Arginine stimulation tests at normo- (5.5 mM) and hyperglycemic (15 mM) levels were performed and the acute insulin, C-peptide and glucagon response (2-5 min) to arginine were determined. Results. Insulin sensitivity (total glucose disposal) was statistically lower in patients treated with FK-506 and CsA (5.05±0.47 and 5.05±0.42 mg/kg/min) as compared to controls (6.62±0.38 mg/kg/min) (P

UR - http://www.scopus.com/inward/record.url?scp=0033610677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033610677&partnerID=8YFLogxK

M3 - Article

VL - 68

SP - 1532

EP - 1541

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 10

ER -