The effects of metal corrosion debris on immune system cells.

M. E. Donati, L. Savarino, D. Granchi, G. Ciapetti, M. Cervellati, R. Rotini, A. Pizzoferrato

Research output: Contribution to journalArticle


Authors evaluated the correlation between immune system and metal ions release in blood of 17 subjects with Cr/Co/Ni joint prostheses. For the purpose Chromium (Cr), Cobalt (Co) and Nickel (Ni) serum levels were measured and, at the same time some immunological parameters (Leukocytes, Lymphocytes and Lymphocytes T, B and Natural Killer cells sub-populations) were evaluated. The results showed a significant decrease of Leukocytes, Lymphocytes and of T Lymphocytes sub-populations. At the same time it was demonstrated a significant increase of Chromium, Cobalt and Nickel levels in patients with joint prostheses as compared to control population (23 patients). In conclusion, ions release from metallic surface of the prostheses is correlated with a depression of immune system. This correlation could depend on a toxic action on immune system caused by the products released by the implant. It could also depend on a lymphocytes compartimentalization in periprosthetic tissues as a consequence of a cell-mediated hypersensitivity reaction towards implants corrosion products.

Original languageEnglish
Pages (from-to)387-393
Number of pages7
JournalLa Chirurgia degli organi di movimento
Issue number4
Publication statusPublished - 1998

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