TY - JOUR
T1 - The effects of oophorectomy on skeletal metabolism
AU - Mazzuoli, G.
AU - Minisola, S.
AU - Bianchi, G.
AU - Pacitti, M. T.
AU - Rosso, R.
AU - Romagnoli, E.
AU - Carnevale, V.
AU - Scarnecchia, L.
AU - Cell, F. S.
AU - Ortore, V.
AU - Carenza, L.
PY - 1990/11/20
Y1 - 1990/11/20
N2 - The effects of oophorectomy on the biological indices of bone remodelling and the time-course of their changes are described. In the first few months following surgical menopause the measurement of the markers of bone remodelling indicates that the increase in osteogenesis is delayed compared with that of bone resorption; this prevalence of destruction over new bone depositon justifies the deficiency of skeletal balance, shortly after acute oestrogen deficiency. The changes in bone remodelling are accompanied by an increase in serum calcium while serum immunoreactive parathyroid hormone levels remain unchanged or even decrease, suggesting a shift to right of the parathyroid gland set-point. The reasons for the negative skeletal balance after oophorectomy might be sought therefore at bone tissue level, even if changes in responsiveness and/or of the parathyroid gland set-point could also be contributory.
AB - The effects of oophorectomy on the biological indices of bone remodelling and the time-course of their changes are described. In the first few months following surgical menopause the measurement of the markers of bone remodelling indicates that the increase in osteogenesis is delayed compared with that of bone resorption; this prevalence of destruction over new bone depositon justifies the deficiency of skeletal balance, shortly after acute oestrogen deficiency. The changes in bone remodelling are accompanied by an increase in serum calcium while serum immunoreactive parathyroid hormone levels remain unchanged or even decrease, suggesting a shift to right of the parathyroid gland set-point. The reasons for the negative skeletal balance after oophorectomy might be sought therefore at bone tissue level, even if changes in responsiveness and/or of the parathyroid gland set-point could also be contributory.
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U2 - 10.1016/0960-0760(90)90498-A
DO - 10.1016/0960-0760(90)90498-A
M3 - Article
C2 - 2257250
AN - SCOPUS:0025649897
VL - 37
SP - 457
EP - 459
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
SN - 0960-0760
IS - 3
ER -