The effects of pregnancy steroids on adaptation of beta cells to pregnancy involve the pancreatic glucose sensor glucokinase

R. Magnaterra, O. Porzio, F. Piemonte, A. Bertoli, G. Sesti, D. Lauro, L. N J L Marlier, G. Federici, P. Borboni

Research output: Contribution to journalArticle

Abstract

Pregnancy is associated with adaptive changes including increased number and size of β cells and enhanced gap-junctional coupling among β cells, increased glucose-induced insulin response and decreased glucose stimulation threshold. The role exerted by pregnancy steroids and lactogenic hormones in the development of islets upregulation during pregnancy has been widely investigated. In the present study we studied the possibility that pregnancy steroids induce functional modifications of β cells involving the expression and function of glucokinase. Our results indicate that estradiol and progesterone do not influence significantly glucokinase mRNA expression, while they induce a dose-dependent and time-dependent increase of glucokinase activity in RIN 1046-38 cells. The increased enzymatic activity results in an increased glucose-induced insulin release. Therefore it is possible to hypothesize that pregnancy steroids influence glucokinase expression in β cells at a post-transcriptional level and that this effect contributes to the development of hyperinsulinemia during pregnancy.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalJournal of Endocrinology
Volume155
Issue number2
DOIs
Publication statusPublished - Nov 1997

ASJC Scopus subject areas

  • Endocrinology

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