The effects of fenfluramine and amphetamine on food intake were studied in midbrain raphe-lesioned or in 6-hydroxydopamine-treated rats. Lesion of the midbrain raphe, which lowers forebrain serotonin, antagonized the anorectic effect of fenfluramine but did not modify the action of amphetamine. An intraventricular injection of 6-hydroxydopamine, which produced a marked decrease of brain noradrenaline and dopamine, did not affect the actions of either amphetamine or fenfluramine. A possible role of brain serotonin and catecholamines on anorexia induced by amphetamine and fenfluramine is discussed.
- Midbrain raphe
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience