The effects of selective lesioning of brain serotonin or catecholamine containing neurones on the anorectic activity of fenfluramine and amphetamine

R. Samanin, D. Ghezzi, L. Valzelli, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of fenfluramine and amphetamine on food intake were studied in midbrain raphe-lesioned or in 6-hydroxydopamine-treated rats. Lesion of the midbrain raphe, which lowers forebrain serotonin, antagonized the anorectic effect of fenfluramine but did not modify the action of amphetamine. An intraventricular injection of 6-hydroxydopamine, which produced a marked decrease of brain noradrenaline and dopamine, did not affect the actions of either amphetamine or fenfluramine. A possible role of brain serotonin and catecholamines on anorexia induced by amphetamine and fenfluramine is discussed.

Original languageEnglish
Pages (from-to)318-322
Number of pages5
JournalEuropean Journal of Pharmacology
Volume19
Issue number3
DOIs
Publication statusPublished - 1972

Keywords

  • 6-OH-dopamine
  • Amphetamine
  • Anorexia
  • Catecholamines
  • Fenfluramine
  • Midbrain raphe
  • Serotonin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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