The effects on pain and activity of daily living caused by crusted exudation in patients with head and neck cancer treated with cetuximab and radiotherapy

Elvio G. Russi, Marco C. Merlano, Gianmauro Numico, Renzo Corvò, Marco Benasso, Riccardo Vigna-Taglianti, Antonella Melano, Nerina Denaro, Stefano Pergolizzi, Ida Colantonio, Francesco Lucio, Rodolfo Brizio, Umberto Ricardi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To date, the specific role of "in-field" crusting exudation on pain and on activity of daily living (ADL) in head and neck cancer (HNSCC) patients undergoing treatment with cetuximab and radiochemotherapy has been neglected. The purpose of the study was to evaluate the role of crusting exudation on the severity of pain and ADL Methods: Thirty-seven of the 45 HNSCC patients enrolled in the alternating radiotherapy, chemotherapy, and cetuximab trial were evaluated in this study. The main radiodermatitis signs (the intensity of erythema, the extension of dry, and moist desquamation and of necrosis)-including crusting exudation severity-pain, ADL, and radiodermatitis scores were registered at least weekly during and after treatment. The correlation between crusting exudation and pain or ADL was evaluated. Results: The "in-field" crusting exudation score seemed to have the strongest correlation with pain (Spearman's rho=0.897; p

Original languageEnglish
Pages (from-to)2141-2147
Number of pages7
JournalSupportive Care in Cancer
Volume20
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Chemoradiotherapy and cetuximab
  • Head and neck cancer
  • Radiodermatitis
  • Skin toxicity

ASJC Scopus subject areas

  • Oncology

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