The efferent mechanisms of reflex hemodynamic responses to distension of the descending colon in anesthetized dogs

A. Cevese, R. Poltronieri, D. A S G Mary, F. Schena, G. Vacca

Research output: Contribution to journalArticle

Abstract

We have recently shown that distension of the descending colon in anesthetized dogs causes reflex increases in heart rate, aortic blood pressure and the maximal rate of rise of left ventricular pressure, involving afferent pathways in the hypogastric nerves. In this study we have examined the efferent mechanisms involved in those responses. The descending colon was distended using Ringer solution at constant pressure in 13 anesthetized dogs. As previously shown, distension of the colon caused an increase in aortic blood pressure, heart rate and the maximal rate of rise of left ventricular pressure. The increase in the aortic blood pressure was abolished by either bretylium tosylate or phentolamine. Propranolol or bretylium tosylate abolished the increases in heart rate when changes in the aortic blood pressure were prevented, and abolished the increases in the maximal rate of rise of left ventricular pressure when the increases in heart rate were also prevented. These results indicate that the reflex increases in heart rate, arterial blood pressure and the maximal rate of rise of left ventricular pressure involved efferent sympathetic pathways.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalCardioscience
Volume2
Issue number4
Publication statusPublished - 1991

Fingerprint

Descending Colon
Reflex
Ventricular Pressure
Arterial Pressure
Heart Rate
Hemodynamics
Dogs
Bretylium Tosylate
Afferent Pathways
Efferent Pathways
Phentolamine
Propranolol
Colon
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The efferent mechanisms of reflex hemodynamic responses to distension of the descending colon in anesthetized dogs. / Cevese, A.; Poltronieri, R.; Mary, D. A S G; Schena, F.; Vacca, G.

In: Cardioscience, Vol. 2, No. 4, 1991, p. 257-262.

Research output: Contribution to journalArticle

Cevese, A. ; Poltronieri, R. ; Mary, D. A S G ; Schena, F. ; Vacca, G. / The efferent mechanisms of reflex hemodynamic responses to distension of the descending colon in anesthetized dogs. In: Cardioscience. 1991 ; Vol. 2, No. 4. pp. 257-262.
@article{609101930a664ffab6a12335c7fda700,
title = "The efferent mechanisms of reflex hemodynamic responses to distension of the descending colon in anesthetized dogs",
abstract = "We have recently shown that distension of the descending colon in anesthetized dogs causes reflex increases in heart rate, aortic blood pressure and the maximal rate of rise of left ventricular pressure, involving afferent pathways in the hypogastric nerves. In this study we have examined the efferent mechanisms involved in those responses. The descending colon was distended using Ringer solution at constant pressure in 13 anesthetized dogs. As previously shown, distension of the colon caused an increase in aortic blood pressure, heart rate and the maximal rate of rise of left ventricular pressure. The increase in the aortic blood pressure was abolished by either bretylium tosylate or phentolamine. Propranolol or bretylium tosylate abolished the increases in heart rate when changes in the aortic blood pressure were prevented, and abolished the increases in the maximal rate of rise of left ventricular pressure when the increases in heart rate were also prevented. These results indicate that the reflex increases in heart rate, arterial blood pressure and the maximal rate of rise of left ventricular pressure involved efferent sympathetic pathways.",
author = "A. Cevese and R. Poltronieri and Mary, {D. A S G} and F. Schena and G. Vacca",
year = "1991",
language = "English",
volume = "2",
pages = "257--262",
journal = "Cardioscience",
issn = "1015-5007",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - The efferent mechanisms of reflex hemodynamic responses to distension of the descending colon in anesthetized dogs

AU - Cevese, A.

AU - Poltronieri, R.

AU - Mary, D. A S G

AU - Schena, F.

AU - Vacca, G.

PY - 1991

Y1 - 1991

N2 - We have recently shown that distension of the descending colon in anesthetized dogs causes reflex increases in heart rate, aortic blood pressure and the maximal rate of rise of left ventricular pressure, involving afferent pathways in the hypogastric nerves. In this study we have examined the efferent mechanisms involved in those responses. The descending colon was distended using Ringer solution at constant pressure in 13 anesthetized dogs. As previously shown, distension of the colon caused an increase in aortic blood pressure, heart rate and the maximal rate of rise of left ventricular pressure. The increase in the aortic blood pressure was abolished by either bretylium tosylate or phentolamine. Propranolol or bretylium tosylate abolished the increases in heart rate when changes in the aortic blood pressure were prevented, and abolished the increases in the maximal rate of rise of left ventricular pressure when the increases in heart rate were also prevented. These results indicate that the reflex increases in heart rate, arterial blood pressure and the maximal rate of rise of left ventricular pressure involved efferent sympathetic pathways.

AB - We have recently shown that distension of the descending colon in anesthetized dogs causes reflex increases in heart rate, aortic blood pressure and the maximal rate of rise of left ventricular pressure, involving afferent pathways in the hypogastric nerves. In this study we have examined the efferent mechanisms involved in those responses. The descending colon was distended using Ringer solution at constant pressure in 13 anesthetized dogs. As previously shown, distension of the colon caused an increase in aortic blood pressure, heart rate and the maximal rate of rise of left ventricular pressure. The increase in the aortic blood pressure was abolished by either bretylium tosylate or phentolamine. Propranolol or bretylium tosylate abolished the increases in heart rate when changes in the aortic blood pressure were prevented, and abolished the increases in the maximal rate of rise of left ventricular pressure when the increases in heart rate were also prevented. These results indicate that the reflex increases in heart rate, arterial blood pressure and the maximal rate of rise of left ventricular pressure involved efferent sympathetic pathways.

UR - http://www.scopus.com/inward/record.url?scp=0026331163&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026331163&partnerID=8YFLogxK

M3 - Article

C2 - 1760517

AN - SCOPUS:0026331163

VL - 2

SP - 257

EP - 262

JO - Cardioscience

JF - Cardioscience

SN - 1015-5007

IS - 4

ER -